Evidence map›Paper›PMID 22305714›Full record

ReviewTrends in immunology2012

Regulatory T cell migration during an immune response.

Yaozhong Ding, Jiangnan Xu, Jonathan S Bromberg

Abstract readReview
In one paragraph

Review in Trends in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 128 citations in OpenAlex.

  1. CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  2. Review
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  4. Review
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  7. Regulatory T cell and endothelial cell crosstalk.Nature reviews. Immunology · 2025
    Review
  8. Loss of effector TNature cardiovascular research · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. iMaterials today. Bio · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yaozhong DingDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jiangnan Xu
Jonathan S Bromberg
University of Maryland, Baltimore · US

Funding

Induction and Migration of Regulatory T Cells: Role of LymphotoxinR01AI062765 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BROMBERG, JONATHAN S · 2005 to 2019
$5.6M
Transplantation Tolerance: T Cell TraffickingR01AI041428 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROMBERG, JONATHAN S · 1997 to 2012
$3.3M
Regulatory T Cells and Lymphatic Endothelial Cells: Regulatory Interactions for Migration and SuppressionR37AI062765 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Jonathan S Bromberg · 2021 to 2026
$2.9M
Lymphoid Structure in ToleranceR01AI072039 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BROMBERG, JONATHAN S · 2007 to 2010
$1.6M
NIAID NIH HHS R01 AI041428NIAID NIH HHS R01 AI062765NIAID NIH HHS R01 AI072039NIAID NIH HHS R37 AI062765
6 · The paper itself

Abstract

CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells migrate into both inflammatory sites and draining lymph nodes (LNs) during an immune response, and have unique and overlaping functions in each location. Current studies suggest that Treg cells in draining LNs and inflamatory sites may not simply be a division of labor, but rather Treg cells migrate in a coordinated fashion between peripheral tissues and draining LNs. Trafficking between inflammatory sites and draining LNs is not only crucial for Treg cells to act, but also for them to acquire optimal immune regulatory activities. Furthermore, recent work has revealed that T helper (Th)1, Th2 and Th17 cell master transcription factors control Treg cell function by regulating genes important for Treg cell migration and suppression, and consequently affect disease pathogenesis.

Indexed as

Cell MovementAnimalsHumansLymph NodesReceptors, Antigen, T-CellT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryReceptors, Antigen, T-Cell

Identifiers

PMID22305714
PMCPMC3319498
OpenAlexW2082014233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.