ArticleBrain research2012
Olfactory ERPs in an odor/visual congruency task differentiate ApoE ε4 carriers from non-carriers.
Article in Brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Assessment and Scientific Progresses in the Analysis of Olfactory Evoked Potentials.Bioengineering (Basel, Switzerland) · 2022Review
- Human APOE ɛ3 and APOE ɛ4 Alleles Have Differential Effects on Mouse Olfactory Epithelium.Journal of Alzheimer's disease : JAD · 2022Article
- Alzheimer's Disease: What Can We Learn From the Peripheral Olfactory System?Frontiers in neuroscience · 2020Review
- Intensity expectation modifies gustatory evoked potentials to sweet taste: Evidence of bidirectional assimilation in early perceptual processing.Psychophysiology · 2019Article
- Review
- Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice.Neuroscience · 2018Article
- Apo E4 Alleles and Impaired Olfaction as Predictors of Alzheimer's Disease.Clinical and experimental psychology · 2017Article
- Amyloid-aβ Peptide in olfactory mucosa and mesenchymal stromal cells of mild cognitive impairment and Alzheimer's disease patients.Brain pathology (Zurich, Switzerland) · 2015Article
- A designated odor-language integration system in the human brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Electroencephalogram and Alzheimer's disease: clinical and research approaches.International journal of Alzheimer's disease · 2014Review
- Time to smell: a cascade model of human olfactory perception based on response-time (RT) measurement.Frontiers in psychology · 2014Review
- Age and apolipoprotein E ε4 effects on neural correlates of odor memory.Behavioral neuroscience · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that impairs memory and semantic processing. AD patients and MCI patients at risk for AD show altered N400 ERP responses to incongruent visual and verbal stimuli. AD patients exhibit neuropathology in olfactory brain areas before cognitive symptoms, suggesting the potential for olfactory processing to reflect early pathology. Despite this, odor congruency has not been examined. We investigated odor-image congruency in older adults at genetic risk for AD. ApoE ε4 carriers and non-carriers were screened for anosmia, severe hyposmia, and dementia. Olfactory ERPs were measured 600-1300 ms following odor-image pairs. Odors were each presented once congruently and once incongruently via an olfactometer. Pz amplitude significantly decreased on incongruent trials in e4 carriers. Pz amplitude differences on congruous and incongruous trials were larger in non carriers. Regression indicated that congruency showed very high sensitivity and specificity for correctly classifying ε4 carriers from non-carriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.