ArticleBiological psychiatry2012
Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence task.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 110 citations in OpenAlex.
- Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior.Nature neuroscience · 2026Article
- A prolactin-receptive neural circuit drives maternal interactions with pups in mice.Science advances · 2026Article
- Striatal Dopamine at Learned Sequence Boundaries Sustains Birdsong.bioRxiv : the preprint server for biology · 2026Article
- Sequence termination cues drive habits via dopamine-mediated credit assignment.bioRxiv : the preprint server for biology · 2025Article
- Nucleus accumbens dynamics in food reward seeking and regulation by sleep.Translational psychiatry · 2025Article
- Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking.Nature communications · 2024Article
- Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation.Cell reports · 2024Article
- State and rate-of-change encoding in parallel mesoaccumbal dopamine pathways.Nature neuroscience · 2024Article
- Inhibitory Pedunculopontine Neurons Gate Dopamine-Mediated Motor Actions of Unsigned Valence.Current neuropharmacology · 2024Article
- Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance.The European journal of neuroscience · 2024Article
- Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation.eLife · 2023Article
- Anticipation of Appetitive Operant Action Induces Sustained Dopamine Release in the Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The nucleus accumbens dopamine increase, typically triggered by sexual stimuli in male rats, is no longer produced when animals are sexually inhibited due to sexual satiety.Psychopharmacology · 2022Article
- Mesoaccumbal Dopamine Heterogeneity: What Do Dopamine Firing and Release Have to Do with It?Annual review of neuroscience · 2022Review
- Phasic Dopamine Changes and Hebbian Mechanisms during Probabilistic Reversal Learning in Striatal Circuits: A Computational Study.International journal of molecular sciences · 2022Article
- The role of state uncertainty in the dynamics of dopamine.Current biology : CB · 2022Article
- Opposing Roles of the Dorsolateral and Dorsomedial Striatum in the Acquisition of Skilled Action Sequencing in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Functional dissociation of behavioral effects from acetylcholine and glutamate released from cholinergic striatal interneurons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- 5-HTPsychopharmacology · 2022Article
4 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
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Abstract
backgroundSequential reward-seeking actions are readily learned despite the temporal gap between the earliest (distal) action in the sequence and the reward delivery. Fast dopamine signaling is hypothesized to mediate this form of learning by reporting errors in reward prediction. However, such a role for dopamine release in voluntarily initiated action sequences remains to be demonstrated.
methodsUsing fast-scan cyclic voltammetry, we monitored phasic mesolimbic dopamine release, in real time, as rats performed a self-initiated sequence of lever presses to earn sucrose rewards. Before testing, rats received either 0 (n = 11), 5 (n = 11), or 10 (n = 8) days of action sequence training.
resultsFor rats acquiring the action sequence task at test, dopamine release was strongly elicited by response-contingent (but unexpected) rewards. With learning, a significant elevation in dopamine release preceded performance of the proximal action and subsequently came to precede the distal action. This predistal dopamine release response was also observed in rats previously trained on the action sequence task, and the amplitude of this signal predicted the latency with which rats completed the action sequence. Importantly, the dopamine response to contingent reward delivery was not observed in rats given extensive pretraining. Pharmacological analysis confirmed that task performance was dopamine-dependent.
conclusionsThese data suggest that phasic mesolimbic dopamine release mediates the influence that rewards exert over the performance of self-paced, sequentially-organized behavior and sheds light on how dopamine signaling abnormalities may contribute to disorders of behavioral control.
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