Trial reportBMC clinical pharmacology2012
Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects.
Trial report in BMC clinical pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00981877 (Probiotics in the Management of Acute Rotavirus Diarrhea in Bolivian Children), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Probiotics in the Management of Acute Rotavirus Diarrhea in Bolivian Children: Randomized Double-blind, Controlled Trial Using Two Different Preparations
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis.Pain medicine (Malden, Mass.) · 2020Pooled it
- Absorption kinetics of vitamins and minerals from a novel nutritional product in physically active adults: a randomized, double-blind, placebo-controlled crossover trial.Frontiers in nutrition · 2026Trial
- Trial
- B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.Molecular medicine (Cambridge, Mass.) · 2023Trial
- Trial
- Supplemental thiamine for the treatment of acute heart failure syndrome: a randomized controlled trial.BMC complementary and alternative medicine · 2019Trial
- Reassessing Transketolase Assays: Methodological Considerations for Detecting Functional Thiamine Deficiency.Annals of the New York Academy of Sciences · 2026Review
- Traceless Regulation of Genetic Circuitry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- HPMC Substitution Influences the Buoyancy and Release in Gastroretentive Floating Tablets.AAPS PharmSciTech · 2026Article
- Thiamine Use in Hospitalized Patients: A Clinical Review.Journal of nutrition and metabolism · 2026Review
- Transporters in vitamin uptake and cellular metabolism: impacts on health and disease.Life metabolism · 2025Review
- Protocols of Thiamine Supplementation: Clinically Driven Rationality vs. Biological Commonsense.Journal of clinical medicine · 2025Article
- Wernicke's Encephalopathy Secondary to Cannabis Hyperemesis Syndrome.Journal of Brown hospital medicine · 2025Article
- Rare Diseases Linked to Mutations in Vitamin Transporters Expressed in the Human Blood-Brain Barrier.Clinical pharmacology and therapeutics · 2024Review
- In Vitro Mucoadhesive Features of Gliadin Nanoparticles Containing Thiamine Hydrochloride.Pharmaceutics · 2024Article
- Whole blood thiamine, intravenous thiamine supplementation and delirium occurrence in the intensive care unit: retrospective cohort analyses.International journal of clinical pharmacy · 2024Article
- Pharmacokinetics of vitamin dosage forms: A complete overview.Food science & nutrition · 2024Review
- In Vivo Evaluation of Thiamine Hydrochloride with Gastro-Retentive Drug Delivery in Healthy Human Volunteers Using Gamma Scintigraphy.Pharmaceutics · 2023Article
- Thiamin (Vitamin BFood & nutrition research · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses in healthy subjects.
methodsThis was a randomized, double-blind, single-dose, 4-way crossover study. Pharmacokinetic measures were calculated.
resultsThe AUC₀₋₁₀ hr and C(max) values increased nonlinearly between 100 mg and 1500 mg. The slope of the AUC₀₋₁₀ hr vs dose, as well as the C(max) vs dose, plots are steepest at the lowest thiamine doses.
conclusionOur study demonstrates that high blood levels of thiamine can be achieved rapidly with oral thiamine hydrochloride. Thiamine is absorbed by both an active and nonsaturable passive process.
trial registrationClinicalTrials.gov: NCT00981877.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.