Evidence map›Paper›PMID 22305021›Full record

ArticleEmerging infectious diseases2012

Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland.

Mira Meriluoto, Lea Hedman, Laura Tanner, Ville Simell, Marjaana Mäkinen, Satu Simell, Juha Mykkänen, Jan Korpelainen, Olli Ruuskanen, Jorma Ilonen and 4 more

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 111 citations in OpenAlex.

  1. Review
  2. Review
  3. Nonclinical strategies and considerations to enable the redosing of gene therapies.Molecular therapy. Methods & clinical development · 2025
    Review
  4. Review
  5. Viruses Associated with Acute Conjunctivitis in Vanuatu.The American journal of tropical medicine and hygiene · 2023
    Article
  6. Article
  7. Human bocavirus-1 infections in Australian children aged < 2 years: a birth cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Role of Human Bocavirus Respiratory Tract Infection in Hematopoietic Cell Transplant Recipients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Viral Respiratory Pathogens and Lung Injury.Clinical microbiology reviews · 2021
    Review
  16. Article
  17. Review
  18. Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020
    Article
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Mira MeriluotoUniversity of Helsinki, Helsinki, Finland.
Lea Hedman
Laura Tanner
Ville Simell
Marjaana Mäkinen
Satu Simell
Juha Mykkänen
Jan Korpelainen
Olli Ruuskanen
Jorma Ilonen
Mikael Knip
Olli Simell
Klaus Hedman
Maria Söderlund-Venermo
Helsinki University Hospital · FITampere University Hospital · FIUniversity of Helsinki · FITampere University · FIUniversity of Eastern Finland · FIFolkhälsans Forskningscentrum · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human bocavirus 1 (HBoV1) DNA is frequently detected in the upper airways of young children with respiratory symptoms. Because of its persistence and frequent co-detection with other viruses, however, its etiologic role has remained controversial. During 2009-2011, using HBoV1 IgM, IgG, and IgG-avidity enzyme immunoassays and quantitative PCR, we examined 1,952 serum samples collected consecutively at 3- to 6-month intervals from 109 constitutionally healthy children from infancy to early adolescence. Primary HBoV1 infection, as indicated by seroconversion, appeared in 102 (94%) of 109 children at a mean age of 2.3 years; the remaining 7 children were IgG antibody positive from birth. Subsequent secondary infections or IgG antibody increases were evident in 38 children and IgG reversions in 10. Comparison of the seroconversion interval with the next sampling interval for clinical events indicated that HBoV1 primary infection, but not secondary immune response, was significantly associated with acute otitis media and respiratory illness.

Indexed as

AdolescentAntibodies, ViralChildChild, PreschoolDNA, ViralFemaleFinlandFollow-Up StudiesHuman bocavirusHumansInfantMaleParvoviridae InfectionsRespiratory Tract InfectionsViremiaAntibodies, ViralDNA, Viral

Identifiers

PMID22305021
PMCPMC3310460
OpenAlexW2161134535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.