Evidence map›Paper›PMID 22304987›Full record

ArticleInternational journal of law and psychiatry

Picturing neuroscience research through a human rights lens: imaging first-episode schizophrenic treatment-naive individuals.

Marleen Eijkholt, James A Anderson, Judy Illes

Abstract read
In one paragraph

Article in International journal of law and psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Neuroethical issues in clinical neuroscience research.Handbook of clinical neurology · 2013
    Review
  5. Article
  6. Neuroimaging in mental health care: voices in translation.Frontiers in human neuroscience · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marleen EijkholtNational Core for Neuroethics, Division of Neurology, the University of British Columbia, 2211 Wesbrook Mall, Koerner S124, Vancouver, BC V6T 2B5, Canada. marleen.neuroethics@gmail.com
James A Anderson
Judy Illes

Funding

Advanced Neuroimaging: Ethical, Legal, and Social IssuesR01MH084282 · NIMH · UNIVERSITY OF BRITISH COLUMBIA · PI ILLES, JUDY · 2008 to 2011
$680k
CIHRNIMH NIH HHS 9R01MH84282NIMH NIH HHS R01 MH084282
6 · The paper itself

Abstract

In this paper we examine imaging research involving first-episode schizophrenic treatment-naive individuals (FESTNIs) through a legal human rights lens; in particular, the lens of the Additional Protocol to the Convention on Human Rights and Biomedicine Concerning Biomedical Research. We identify a number of ethical and legal hot spots highlighted by the Protocol, and offer a series of recommendations designed to ensure the human rights compatibility of this research. Subsequently, we argue that the lack of reporting on design elements related to ethical concerns frustrates commitments at the heart of the human rights approach, namely, transparency and openness to international scrutiny. To redress this problem, we introduce two norms for the first time: ethical transparency, and ethical reproducibility. When concluding, we offer a set of reporting guidelines designed to operationalize these norms in the context of imaging research involving FESTNIs. Though we will not make this case here, we believe that parallel reporting guidelines should be incorporated into other areas of research involving human subjects.

Indexed as

Human RightsCanadaHuman ExperimentationHumansInformed ConsentNeuroimagingPatient SafetyPractice Guidelines as TopicSchizophrenia

Identifiers

PMID22304987
PMCPMC3329217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.