ArticleCell2012
Optimality in the development of intestinal crypts.
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
89 citing papers in PubMed.
- Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition.Cell stem cell · 2026Article
- Optimality as a framework for understanding developmental robustness.Trends in cell biology · 2026Review
- Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway.iMetaOmics · 2026Article
- Cell cycle criticality as a mechanism for robust cell population control.Molecular systems biology · 2026Article
- Initial pig developmental stage influences intestinal organoid growth but not cellular composition.Animal models and experimental medicine · 2024Article
- Review
- Age-Dependent Differences in Radiation-Induced DNA Damage Responses in Intestinal Stem Cells.International journal of molecular sciences · 2024Article
- Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila.Developmental cell · 2024Article
- Challenges and opportunities in cell expansion for cultivated meat.Frontiers in nutrition · 2024Article
- Modulating cell proliferation by asymmetric division: A conserved pattern in the early embryogenesis of nematode species.microPublication biology · 2024Article
- Adult stem cell activity in naked mole rats for long-term tissue maintenance.Nature communications · 2023Article
- Article
- In-silico and in-vitro morphometric analysis of intestinal organoids.PLoS computational biology · 2023Article
- Smooth muscle contributes to the development and function of a layered intestinal stem cell niche.Developmental cell · 2023Article
- Article
- Article
- Tissue Homeostasis and Non-Homeostasis: From Cell Life Cycles to Organ States.Annual review of cell and developmental biology · 2022Review
- Mathematical modelling identifies conditions for maintaining and escaping feedback control in the intestinal epithelium.Scientific reports · 2022Article
- ECM degradation in the Drosophila abdominal epidermis initiates tissue growth that ceases with rapid cell-cycle exit.Current biology : CB · 2022Article
- Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model.BMC biology · 2021Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Intestinal crypts in mammals are comprised of long-lived stem cells and shorter-lived progenies. These two populations are maintained in specific proportions during adult life. Here, we investigate the design principles governing the dynamics of these proportions during crypt morphogenesis. Using optimal control theory, we show that a proliferation strategy known as a "bang-bang" control minimizes the time to obtain a mature crypt. This strategy consists of a surge of symmetric stem cell divisions, establishing the entire stem cell pool first, followed by a sharp transition to strictly asymmetric stem cell divisions, producing nonstem cells with a delay. We validate these predictions using lineage tracing and single-molecule fluorescence in situ hybridization of intestinal crypts in infant mice, uncovering small crypts that are entirely composed of Lgr5-labeled stem cells, which become a minority as crypts continue to grow. Our approach can be used to uncover similar design principles in other developmental systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.