ReviewAnnals of the New York Academy of Sciences2012
Mouse models for studying genetic influences on factors determining smoking cessation success in humans.
Review in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Strain-specific altered nicotine metabolism in 3,3'-diindolylmethane (DIM) exposed mice.Biopharmaceutics & drug disposition · 2019Article
- Aerobic and concentration training and allele 7 in the dopamine receptor D4 (Archives of medical science : AMS · 2018Article
- The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction.Neural plasticity · 2018Review
- Negative affective states and cognitive impairments in nicotine dependence.Neuroscience and biobehavioral reviews · 2015Review
- Nine generations of selection for high and low nicotine intake in outbred Sprague-Dawley rats.Behavior genetics · 2013Article
- Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine.Neuropharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Humans differ in their ability to quit using addictive substances, including nicotine, the major psychoactive ingredient in tobacco. For tobacco smoking, a substantial body of evidence, largely derived from twin studies, indicates that approximately half of these individual differences in ability to quit are heritable genetic influences that likely overlap with those for other addictive substances. Both twin and molecular genetic studies support overlapping influences on nicotine addiction vulnerability and smoking cessation success, although there is little formal analysis of the twin data that support this important point. None of the current datasets provides clarity concerning which heritable factors might provide robust dimensions around which individuals differ in ability to quit smoking. One approach to this problem is to test mice with genetic variations in genes that contain human variants that alter quit success. This review considers which features of quit success should be included in a comprehensive approach to elucidate the genetics of quit success, and how those features may be modeled in mice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.