Evidence map›Paper›PMID 22303480›Full record

ArticlePloS one2012

PKCθ synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1.

Hirofumi Jono, Jae Hyang Lim, Haidong Xu, Jian-Dong Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The Novel PKCθ from Benchtop to Clinic.Journal of immunology research · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hirofumi JonoDepartment of Microbiology & Immunology, University of Rochester Medical Center, Rochester, New York, United States of America.
Jae Hyang Lim
Haidong Xu
Jian-Dong Li
University of Rochester Medical Center · USGeorgia State University · US

Funding

Combinational Regulation of Inflammation in Otitis MediaR01DC005843 · NIDCD · UNIVERSITY OF ROCHESTER · PI LI, JIAN-DONG · 2002 to 2016
$5.4M
UP REGULATION OF MUCIN GENE TRANSCRIPTION--OTITIS MEDIAR01DC004562 · NIDCD · UNIVERSITY OF ROCHESTER · PI LI, JIAN-DONG · 2000 to 2014
$4.7M
Regulation of Host Response in S. pneumoniae InfectionsR01AI073374 · NIAID · UNIVERSITY OF ROCHESTER · PI LI, JIAN-DONG · 2009 to 2010
$741k
NIAID NIH HHS AI073374NIAID NIH HHS R01 AI073374NIDCD NIH HHS DC004562NIDCD NIH HHS DC005843NIDCD NIH HHS DC005843-S1NIDCD NIH HHS R01 DC004562NIDCD NIH HHS R01 DC005843
6 · The paper itself

Abstract

CARD-containing MAGUK protein 1 (CARMA1) plays a crucial role in regulating adaptive immune responses upon T-cell receptor (TCR) activation in T cells. Its role in regulating host mucosal innate immune response such as upregulation of mucin remains unknown. Here we show that CARMA1 acts as a key signaling mediator for synergistic upregulation of MUC5AC mucin by bacterium nontypeable Haemophilus influenzae (NTHi) and phorbol ester PMA in respiratory epithelial cells. NTHi-induced TLR-dependent TRAF6-MKK3-p38 MAPK signaling pathway synergizes with PKCθ-MEK-ERK signaling pathway. CARMA1 plays a crucial role in mediating this synergistic effect via TRAF6, thereby resulting in synergistic upregulation of MUC5AC mucin. Thus our study unveils a novel role for CARMA1 in mediating host mucosal innate immune response.

Indexed as

Signal TransductionUp-RegulationAnimalsCARD Signaling Adaptor ProteinsCell LineEpithelial CellsGuanylate CyclaseHaemophilus influenzaeHumansIsoenzymesMAP Kinase Kinase 3MAP Kinase Kinase 6MAP Kinase Signaling SystemMembrane ProteinsMiceMucin 5ACCARD11 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseIsoenzymesMAP Kinase Kinase 3MAP Kinase Kinase 6Membrane ProteinsMucin 5ACp38 Mitogen-Activated Protein KinasesPRKCQ protein, humanProtein Kinase CProtein Kinase C-thetaTetradecanoylphorbol AcetateTNF Receptor-Associated Factor 6Toll-Like Receptor 2

Identifiers

PMID22303480
PMCPMC3267763
OpenAlexW2075192688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.