Evidence map›Paper›PMID 22303474›Full record

SynthesisPloS one2012

The efficacy of exercise in reducing depressive symptoms among cancer survivors: a meta-analysis.

Justin C Brown, Tania B Huedo-Medina, Linda S Pescatello, Stacey M Ryan, Shannon M Pescatello, Emily Moker, Jessica M LaCroix, Rebecca A Ferrer, Blair T Johnson

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01990430 (Integrative Exercise and Life Style Intervention Increase Leisure Time Activity in Breast Cancer Patients.), which is not on this map. Cited by 90 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 16 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01990430 naunknown statusnot on this mapstarted 2013, after this paper: background citation

Integrative Exercise and Life Style Intervention Increase Leisure Time Activity in Breast Cancer Patients.

TypeinterventionalSponsorUniversidad Politecnica de MadridRan2013 to 2014Enrolled60ConditionsQuality of LifeArmsExercise Intervention
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 16 syntheses or guidelines pooled it, 196 citations in OpenAlex.

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  14. Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Justin C BrownCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. brownjus@mail.med.upenn.edu
Tania B Huedo-Medina
Linda S Pescatello
Stacey M Ryan
Shannon M Pescatello
Emily Moker
Jessica M LaCroix
Rebecca A Ferrer
Blair T Johnson
University of Connecticut · USNational Cancer Institute · USThe University of Texas MD Anderson Cancer Center · USTranslational Therapeutics (United States) · USWestern New England University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe purpose of this meta-analysis was to examine the efficacy of exercise to reduce depressive symptoms among cancer survivors. In addition, we examined the extent to which exercise dose and clinical characteristics of cancer survivors influence the relationship between exercise and reductions in depressive symptoms.

methodsWe conducted a systematic search identifying randomized controlled trials of exercise interventions among adult cancer survivors, examining depressive symptoms as an outcome. We calculated effect sizes for each study and performed weighted multiple regression moderator analysis.

resultsWe identified 40 exercise interventions including 2,929 cancer survivors. Diverse groups of cancer survivors were examined in seven exercise interventions; breast cancer survivors were examined in 26; prostate cancer, leukemia, and lymphoma were examined in two; and colorectal cancer in one. Cancer survivors who completed an exercise intervention reduced depression more than controls, d(+) = -0.13 (95% CI: -0.26, -0.01). Increases in weekly volume of aerobic exercise reduced depressive symptoms in dose-response fashion (β = -0.24, p = 0.03), a pattern evident only in higher quality trials. Exercise reduced depressive symptoms most when exercise sessions were supervised (β = -0.26, p = 0.01) and when cancer survivors were between 47-62 yr (β = 0.27, p = 0.01).

conclusionExercise training provides a small overall reduction in depressive symptoms among cancer survivors but one that increased in dose-response fashion with weekly volume of aerobic exercise in high quality trials. Depressive symptoms were reduced to the greatest degree among breast cancer survivors, among cancer survivors aged between 47-62 yr, or when exercise sessions were supervised.

Indexed as

Exercise TherapyAdultAgedDepressionFemaleHumansMaleMiddle AgedNeoplasmsSurvivorsTreatment Outcome

Identifiers

PMID22303474
PMCPMC3267760
OpenAlexW2062270028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.