ArticleFrontiers in genetics2012
Moving toward System Genetics through Multiple Trait Analysis in Genome-Wide Association Studies.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed.
- Article
- Identifying pleiotropic genes via the composite test amidst the complexity of polygenic traits.Briefings in bioinformatics · 2024Article
- A copula-based set-variant association test for bivariate continuous, binary or mixed phenotypes.The international journal of biostatistics · 2023Article
- Article
- Multivariate phenotype analysis enables genome-wide inference of mammalian gene function.PLoS biology · 2022Article
- Article
- Multivariate Analysis and Modelling of multiple Brain endOphenotypes: Let's MAMBO!Computational and structural biotechnology journal · 2021Review
- Genetic correlations of polygenic disease traits: from theory to practice.Nature reviews. Genetics · 2019Review
- Bayesian multivariate reanalysis of large genetic studies identifies many new associations.PLoS genetics · 2019Article
- Article
- Multivariate generalized linear model for genetic pleiotropy.Biostatistics (Oxford, England) · 2019Article
- PCA-Based Multiple-Trait GWAS Analysis: A Powerful Model for Exploring Pleiotropy.Animals : an open access journal from MDPI · 2018Article
- A genetic stochastic process model for genome-wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data.Genetic epidemiology · 2017Article
- Statistical methods to detect pleiotropy in human complex traits.Open biology · 2017Review
- A quadratically regularized functional canonical correlation analysis for identifying the global structure of pleiotropy with NGS data.PLoS computational biology · 2017Article
- Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.Nature communications · 2017Article
- A rare-variant test for high-dimensional data.European journal of human genetics : EJHG · 2017Article
- MARV: a tool for genome-wide multi-phenotype analysis of rare variants.BMC bioinformatics · 2017Article
- graph-GPA: A graphical model for prioritizing GWAS results and investigating pleiotropic architecture.PLoS computational biology · 2017Article
- SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes.BMC bioinformatics · 2017Article
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Abstract
Association studies are a staple of genotype-phenotype mapping studies, whether they are based on single markers, haplotypes, candidate genes, genome-wide genotypes, or whole genome sequences. Although genetic epidemiological studies typically contain data collected on multiple traits which themselves are often correlated, most analyses have been performed on single traits. Here, I review several methods that have been developed to perform multiple trait analysis. These methods range from traditional multivariate models for systems of equations to recently developed graphical approaches based on network theory. The application of network theory to genetics is termed systems genetics and has the potential to address long-standing questions in genetics about complex processes such as coordinate regulation, homeostasis, and pleiotropy.
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