Evidence map›Paper›PMID 22303398›Full record

ArticleFrontiers in genetics2011

MicroRNAs - Important Molecules in Lung Cancer Research.

Petra Leidinger, Andreas Keller, Eckart Meese

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02445924 (Micro RNA Genetic Signature in Non-small Cell Lung Cancer Egyptian Patients), which is not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02445924 completednot on this mapstarted 2015, after this paper: background citation

Micro RNA Genetic Signature in Non-small Cell Lung Cancer Egyptian Patients

TypeobservationalSponsorAdel Salah BediwyRan2015 to 2016Enrolled40ConditionsNon-small Cell Lung Cancer
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 49 citations in OpenAlex.

  1. Computational and Bioinformatics Methods for MicroRNA Gene Prediction.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  2. Role of microRNAs in Obesity-Related Kidney Disease.International journal of molecular sciences · 2021
    Review
  3. Article
  4. Oncogenic role ofAutophagy · 2021
    Article
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  8. Frontiers in genetics · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Petra LeidingerInstitute of Human Genetics, Medical School, Saarland University Homburg, Germany.
Andreas Keller
Eckart Meese
Saarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNA) are important regulators of gene expression. They are involved in many physiological processes ensuring the cellular homeostasis of human cells. Alterations of the miRNA expression have increasingly been associated with pathophysiologic changes of cancer cells making miRNAs currently to one of the most analyzed molecules in cancer research. Here, we provide an overview of miRNAs in lung cancer. Specifically, we address biological functions of miRNAs in lung cancer cells, miRNA signatures generated from tumor tissue and from patients' body fluids, the potential of miRNAs as diagnostic and prognostic biomarker for lung cancer, and its role as therapeutic target.

Indexed as

biomarkerbloodbody fluidsdiagnosislung cancermicroRNAprognosistherapy

Identifiers

PMID22303398
PMCPMC3263430
OpenAlexW2073050603

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.