ArticleFrontiers in genetics2011
Trans-splicing in Higher Eukaryotes: Implications for Cancer Development?
Article in Frontiers in genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Advancements in Focal Amplification Detection in Tumor/Liquid Biopsies and Emerging Clinical Applications.Genes · 2023Review
- Chimeric RNAs Discovered by RNA Sequencing and Their Roles in Cancer and Rare Genetic Diseases.Genes · 2022Review
- RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells.PLoS genetics · 2021Article
- A community challenge to evaluate RNA-seq, fusion detection, and isoform quantification methods for cancer discovery.Cell systems · 2021Article
- Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival.Cancer research · 2021Article
- Article
- Non-coding RNAs in cancers with chromosomal rearrangements: the signatures, causes, functions and implications.Journal of molecular cell biology · 2019Review
- Novel K6-K14 keratin fusion enhances cancer stemness and aggressiveness in oral squamous cell carcinoma.Oncogene · 2019Article
- RNA-mediated gene fusion in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Landscape and Implications of Chimeric RNAs in Cervical Cancer.EBioMedicine · 2018Article
- MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences.Leukemia · 2018Article
- Review
- It Is Imperative to Establish a Pellucid Definition of Chimeric RNA and to Clear Up a Lot of Confusion in the Relevant Research.International journal of molecular sciences · 2017Review
- Intergenically Spliced Chimeric RNAs in Cancer.Trends in cancer · 2016Review
- Recurrent chimeric fusion RNAs in non-cancer tissues and cells.Nucleic acids research · 2016Article
- Evolutionary Insights into RNA trans-Splicing in Vertebrates.Genome biology and evolution · 2016Review
- The emerging complexity of gene fusions in cancer.Nature reviews. Cancer · 2015Review
- Hypothesis: Artifacts, Including Spurious Chimeric RNAs with a Short Homologous Sequence, Caused by Consecutive Reverse Transcriptions and Endogenous Random Primers.Journal of Cancer · 2015Review
- The role of canonical and noncanonical pre-mRNA splicing in plant stress responses.BioMed research international · 2013Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trans-splicing, the possibility of exons from distinct pre-mRNAs to join together, is still a concept in gene expression that is generally regarded of limited significance. However, recent work has provided evidence that in human tumors trans-splicing events may precede chromosomal rearrangements. In fact, it has been suggested that the trans-spliced molecules could act as "guides" that facilitate the genomic translocation. This perspective highlights the development of the ideas of trans-splicing in higher eukaryotes during the last 25 years, from a bizarre phenomenon to a biological event that is attaining stronger recognition.
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