ArticleFrontiers in microbiology2012
Origin and evolution of antibiotic resistance: the common mechanisms of emergence and spread in water bodies.
Article in Frontiers in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
110 citing papers in PubMed, 1 synthesis or guideline pooled it, 398 citations in OpenAlex.
- Structure of Bacterial Community with Resistance to Antibiotics in Aquatic Environments. A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Medicinal Plants: A Promising Therapeutic Approach for Addressing Antimicrobial Resistance.International journal of molecular sciences · 2026Review
- Occurrence and Genomic Characterization of ESBL-, AmpC-, and Carbapenemase-ProducingMicroorganisms · 2026Article
- The Role of Water as a Reservoir for Antibiotic-Resistant Bacteria.Antibiotics (Basel, Switzerland) · 2025Review
- Bacterivorous CiliateAntibiotics (Basel, Switzerland) · 2025Article
- Phytotoxicity Assessment ofPlants (Basel, Switzerland) · 2025Article
- Investigation of Antibiotic Resistance ofMicroorganisms · 2024Article
- Impact of Predation by CiliateAntibiotics (Basel, Switzerland) · 2024Article
- Subminimum Inhibitory Concentrations Tetracycline Antibiotics Induce Biofilm Formation in Minocycline-ResistantACS infectious diseases · 2024Article
- TC-14, a cathelicidin-derived antimicrobial peptide with broad-spectrum antibacterial activity and high safety profile.iScience · 2024Article
- Insights into the Versatility of Using Atomic Absorption Spectrometry in Antibacterial Research.Molecules (Basel, Switzerland) · 2024Article
- Resistome in a changing environment: Hotspots and vectors of spreading with a focus on the Russian-Ukrainian War.Heliyon · 2024Review
- Genomic characterization of antimicrobial resistance in 61 aquatic bacterial isolates.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Predicting Antibiotic Resistance and Assessing the Risk Burden from Antibiotics: A Holistic Modeling Framework in a Tropical Reservoir.Environmental science & technology · 2024Article
- Camel-Derived Nanobodies as Potent Inhibitors of New Delhi Metallo-β-Lactamase-1 Enzyme.Molecules (Basel, Switzerland) · 2024Article
- Revealing antibiotic resistance's ancient roots: insights from pristine ecosystems.Frontiers in microbiology · 2024Review
- Emerging challenges in antimicrobial resistance: implications for pathogenic microorganisms, novel antibiotics, and their impact on sustainability.Frontiers in microbiology · 2024Review
- Unveiling the Microbiome Landscape: A Metagenomic Study of Bacterial Diversity, Antibiotic Resistance, and Virulence Factors in the Sediments of the River Ganga, India.Antibiotics (Basel, Switzerland) · 2023Article
- Pharmaceutical effluent evokes superbugs in the environment: A call to action.Biosafety and health · 2023Review
- Occurrence of Antibiotic-Resistant Bacteria in Fish and Seafood from Slovak Market.Foods (Basel, Switzerland) · 2023Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The environment, and especially freshwater, constitutes a reactor where the evolution and the rise of new resistances occur. In water bodies such as waste water effluents, lakes, and rivers or streams, bacteria from different sources, e.g., urban, industrial, and agricultural waste, probably selected by intensive antibiotic usage, are collected and mixed with environmental species. This may cause two effects on the development of antibiotic resistances: first, the contamination of water by antibiotics or other pollutants lead to the rise of resistances due to selection processes, for instance, of strains over-expressing broad range defensive mechanisms, such as efflux pumps. Second, since environmental species are provided with intrinsic antibiotic resistance mechanisms, the mixture with allochthonous species is likely to cause genetic exchange. In this context, the role of phages and integrons for the spread of resistance mechanisms appears significant. Allochthonous species could acquire new resistances from environmental donors and introduce the newly acquired resistance mechanisms into the clinics. This is illustrated by clinically relevant resistance mechanisms, such as the fluoroquinolones resistance genes qnr. Freshwater appears to play an important role in the emergence and in the spread of antibiotic resistances, highlighting the necessity for strategies of water quality improvement. We assume that further knowledge is needed to better understand the role of the environment as reservoir of antibiotic resistances and to elucidate the link between environmental pollution by anthropogenic pressures and emergence of antibiotic resistances. Only an integrated vision of these two aspects can provide elements to assess the risk of spread of antibiotic resistances via water bodies and suggest, in this context, solutions for this urgent health issue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.