ArticleThe American journal of tropical medicine and hygiene2012
Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil.
Article in The American journal of tropical medicine and hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Population level changes in schistosome-specific antibody levels following chemotherapy.Parasite immunology · 2019Pooled it
- Host determinants of reinfection with schistosomes in humans: a systematic review and meta-analysis.PLoS neglected tropical diseases · 2014Pooled it
- T cell responses in repeated controlled human schistosome infection compared to natural exposure.Nature communications · 2025Trial
- Article
- High Schistosoma mansoni infection intensity is associated with distinct gut microbiota and low levels of systemic cytokines in children along the Albert-Nile, Northern Uganda.BMC microbiology · 2025Article
- Analysis of miR-10a and IFNG Expression Before and After Treatment for Chronic Schistosomiasis mansoni.Parasite immunology · 2025Article
- Schistosomiasis Chemotherapy, Chemoprevention, and Vaccines: History, Progress, and Priorities.Immunity, inflammation and disease · 2024Review
- Nutritional Status and Quality of Life: Urban-Rural Disparities and the Impact of Obesity.International journal of environmental research and public health · 2024Article
- Profile of T and B lymphocytes in individuals resistant to Schistosoma mansoni infection.Parasitology research · 2022Article
- Immunological Considerations forFrontiers in immunology · 2021Review
- Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development.Research and reports in tropical medicine · 2020Review
- Comparative analysis of transcriptional profiles of Schistosoma japonicum adult worms derived from primary-infected and re-infected water buffaloes.Parasites & vectors · 2019Article
- Diagnosis of Schistosoma mansoni infections: what are the choices in Brazilian low-endemic areas?Memorias do Instituto Oswaldo Cruz · 2019Review
- Is arachidonic acid an endoschistosomicide?Journal of advanced research · 2018Article
- Long-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected withFrontiers in immunology · 2017Article
- Immunology of human schistosomiasis.Parasite immunology · 2014Review
- Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Detailed knowledge of factors associated with resistance to Schistosoma mansoni infection in endemic areas might facilitate more effective schistosomiasis control. We conducted a cross-sectional study of persons resistant to schistosomiasis and found no association between socioeconomic status and resistance to infection. Mononuclear cells of resistant subjects produced higher levels of interleukin-5 (IL-5), IL-13 and interferon-γ upon stimulation with soluble egg antigen (SEA) compared with infected persons. When stimulated with Sm21.6 or Sm22.6, levels of IL-10 were higher in cell culture of resistant persons. Levels of IgE against soluble adult worm antigen (SWAP) and against interleukin-4-inducing principle from S. mansoni eggs (IPSE) and levels of IgG4 against SWAP, SEA, and Sm22.6 were lower in the resistant group compared with the susceptible group. Our data suggest that socioeconomic status could not fully explain resistance to S. mansoni infection observed in the studied area. However, a mixture of Th1 and Th2 immune responses and low levels of specific IgG4 against parasite antigens could be mediating resistance to infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.