ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus--possible basis for tinnitus-related hyperactivity?
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 2 of them syntheses that pooled it.
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Who cites it
104 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychoacoustic characteristics of tinnitus in temporomandibular disorders: a systematic review.CoDAS · 2026Pooled it
- Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis.Frontiers in neuroscience · 2021Pooled it
- Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans.Science translational medicine · 2018Trial
- Impacts of Kv3.1 Channels on Action Potentials in Fusiform Neurons From the Dorsal Cochlear Nucleus of Mice Before and After Hearing Onset.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- A discrete serotonergic circuit involved in the generation of tinnitus behavior.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Scrt1-iCreER: An Inducible Mouse Model for Genetic Access to Type I Spiral Ganglion and Cochlear Nucleus Neurons.Molecular neurobiology · 2026Article
- Association between postzoster neuralgia and tinnitus: A retrospective population-based cohort study.Medicine · 2026Article
- NMDA Receptors: Next therapeutic targets for Tinnitus?Biochemistry and biophysics reports · 2025Review
- Speech recognition thresholds correlate with tinnitus intensity in individuals with primary subjective tinnitus.Frontiers in neurology · 2025Article
- Distinct changes in the morphology of cortical and subcortical grey matter associated with age-related hearing loss and tinnitus in the UK Biobank participants.Brain communications · 2025Article
- Transcriptional profile changes caused by noise-induced tinnitus in the cochlear nucleus and inferior colliculus of the rat.Annals of medicine · 2024Article
- Could DTI Unlock the Mystery of Subjective Tinnitus: It's Time for Parameters That Go A Little Out of the Routine.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Candidate Key Proteins in Tinnitus-A Bioinformatic Study of Synaptic Transmission in the Cochlear Nucleus.Biomedicines · 2024Article
- Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception.Brain : a journal of neurology · 2023Review
- Tinnitus is associated with improved cognitive performance and speech perception-Can stochastic resonance explain?Frontiers in aging neuroscience · 2022Article
- Intrinsic Noise Improves Speech Recognition in a Computational Model of the Auditory Pathway.Frontiers in neuroscience · 2022Article
- Tinnitus-like "hallucinations" elicited by sensory deprivation in an entropy maximization recurrent neural network.PLoS computational biology · 2021Article
- Simulated transient hearing loss improves auditory sensitivity.Scientific reports · 2021Article
- Role of microRNA‑375‑3p‑mediated regulation in tinnitus development.International journal of molecular medicine · 2021Article
- Bimodal Auditory Electrical Stimulation for the Treatment of Tinnitus: Preclinical and Clinical Studies.Current topics in behavioral neurosciences · 2021Article
44 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
The dorsal cochlear nucleus (DCN) is the first neural site of bimodal auditory-somatosensory integration. Previous studies have shown that stimulation of somatosensory pathways results in immediate suppression or enhancement of subsequent acoustically evoked discharges. In the unimpaired auditory system suppression predominates. However, damage to the auditory input pathway leads to enhancement of excitatory somatosensory inputs to the cochlear nucleus, changing their effects on DCN neurons (Shore et al., 2008; Zeng et al., 2009). Given the well described connection between the somatosensory system and tinnitus in patients we sought to determine whether plastic changes in long-lasting bimodal somatosensory-auditory processing accompany tinnitus. Here we demonstrate for the first time in vivo long-term effects of somatosensory inputs on acoustically evoked discharges of DCN neurons in guinea pigs. The effects of trigeminal nucleus stimulation are compared between normal-hearing animals and animals overexposed with narrow band noise and behaviorally tested for tinnitus. The noise exposure resulted in a temporary threshold shift in auditory brainstem responses but a persistent increase in spontaneous and sound-evoked DCN unit firing rates and increased steepness of rate-level functions. Rate increases were especially prominent in buildup units. The long-term somatosensory enhancement of sound-evoked responses was strengthened while suppressive effects diminished in noise-exposed animals, especially those that developed tinnitus. Damage to the auditory nerve is postulated to trigger compensatory long-term synaptic plasticity of somatosensory inputs that might be an important underlying mechanism for tinnitus generation.
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