ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Organization of vomeronasal sensory coding revealed by fast volumetric calcium imaging.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- Effects of acute intranasal allergen exposure on resident immune cells and sensory neurons in the mouse olfactory epithelium.bioRxiv : the preprint server for biology · 2026Article
- Bile acid chemosensation in mammals supports species and gut microbiome evaluation.bioRxiv : the preprint server for biology · 2026Article
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Predicting synchronous firing of large neural populations from sequential recordings.PLoS computational biology · 2021Article
- Paradoxically Sparse Chemosensory Tuning in Broadly Integrating External Granule Cells in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Physiology-forward identification of bile acid-sensitive vomeronasal receptors.Science advances · 2020Article
- Sensory coding mechanisms revealed by optical tagging of physiologically defined neuronal types.Science (New York, N.Y.) · 2019Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- Excreted Steroids in Vertebrate Social Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Experience-Dependent Plasticity Drives Individual Differences in Pheromone-Sensing Neurons.Neuron · 2016Article
- Faecal bile acids are natural ligands of the mouse accessory olfactory system.Nature communications · 2016Article
- Synchronous Drosophila circadian pacemakers display nonsynchronous Ca²⁺ rhythms in vivo.Science (New York, N.Y.) · 2016Article
- Neural map formation and sensory coding in the vomeronasal system.Cellular and molecular life sciences : CMLS · 2015Review
- Article
- Mammalian pheromones: emerging properties and mechanisms of detection.Current opinion in neurobiology · 2015Review
- Dual processing of sulfated steroids in the olfactory system of an anuran amphibian.Frontiers in cellular neuroscience · 2015Article
- Functional organization of glomerular maps in the mouse accessory olfactory bulb.Nature neuroscience · 2014Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
A long-standing goal in neuroscience is to perform exhaustive recording of each neuron in a functional local circuit. To achieve this goal, one promising approach is optical imaging of fluorescent calcium indicators, but typically the tens or hundreds of cells imaged simultaneously comprise only a tiny percentage of the neurons in an intact circuit. Here, we show that a recent innovation, objective-coupled planar illumination (OCPI) microscopy, permits simultaneous recording from three-dimensional volumes containing many thousand neurons. We used OCPI microscopy to record chemosensory responses in the mouse vomeronasal epithelium, for which expression of hundreds of receptor types implies high functional diversity. The implications of this diversity for sensory coding were examined using several classes of previously reported vomeronasal ligands, including sulfated steroids. A collection of just 12 sulfated steroids activated more than a quarter of the neurons in the apical vomeronasal epithelium; unexpectedly, responses were functionally organized into a modest number of classes with characteristic spatial distribution. Recording from a whole sensory system thus revealed new organizational principles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.