ArticleChemphyschem : a European journal of chemical physics and physical chemistry2012
Defining a polymethine dye for fluorescence anisotropy applications in the near-infrared spectral range.
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Solvent Polarity Dependent Ultrafast Relaxation Kinetics of ADS800AT Dye.Journal of fluorescence · 2025Article
- PEGylated peptide to TIP1 is a novel targeting agent that binds specifically to various cancers in vivo.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- Cell-free measurements of brightness of fluorescently labeled antibodies.Scientific reports · 2017Article
- Imaging of radicals following injury or acute stress in peripheral nerves with activatable fluorescent probes.Free radical biology & medicine · 2016Article
- Nanothermometry: From Microscopy to Thermal Treatments.Chemphyschem : a European journal of chemical physics and physical chemistry · 2016Review
- Visualization of pulmonary clearance mechanisms via noninvasive optical imaging validated by near-infrared flow cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2015Article
- Fluorescence anisotropy (polarization): from drug screening to precision medicine.Expert opinion on drug discovery · 2015Review
- Multispectral measurement of contrast in tissue-mimicking phantoms in near-infrared spectral range of 650 to 1600 nm.Journal of biomedical optics · 2014Article
- Holistic assessment of covalently labeled core-shell polymeric nanoparticles with fluorescent contrast agents for theranostic applications.Langmuir : the ACS journal of surfaces and colloids · 2014Article
- Evaluation of inflammatory response to acute ischemia using near-infrared fluorescent reactive oxygen sensors.Molecular imaging and biology · 2013Article
- BLOOD TRIGGERED RAPID RELEASE POROUS NANOCAPSULES.RSC advances · 2013Article
- Minimization of self-quenching fluorescence on dyes conjugated to biomolecules with multiple labeling sites via asymmetrically charged NIR fluorophores.Contrast media & molecular imagingArticle
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Authors and funding
4 authors.
Funding
Abstract
Fluorescence anisotropy in the near-infrared (NIR) spectral range is challenging because of the lack of appropriate NIR fluorescent labels. We have evaluated polymethine fluorescent dyes to identify a leading candidate for NIR anisotropy applications. The NIR dye LS601 demonstrated low fluorescence anisotropy values (r) as a result of its relatively long fluorescent lifetime 1.3 ns. The r value of LS601 unbound and coupled to biological macromolecules was found to have a sufficient dynamic range from 0.24 to 0.37, demonstrating the feasibility of fluorescence anisotropy in the NIR. The viability of fluorescence anisotropy using a NIR label was demonstrated by characterization of dye-protein conjugates. These results open the door to a number of applications in drug discovery, fluorescence anisotropy imaging and contrast agent development.
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