Evidence map›Paper›PMID 22302620›Full record

ArticleJournal of genetic counseling2012

Genetic counseling as a tool for type 2 diabetes prevention: a genetic counseling framework for common polygenetic disorders.

Jessica L Waxler, Kelsey E O'Brien, Linda M Delahanty, James B Meigs, Jose C Florez, Elyse R Park, Barbara R Pober, Richard W Grant

Registry-linked trialAbstract read
In one paragraph

Article in Journal of genetic counseling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01034319 (Genetic Counseling and Lifestyle Change for Diabetes Prevention), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01034319 phase2unknown statusnot on this map

Genetic Counseling and Lifestyle Change for Diabetes Prevention

TypeinterventionalSponsorMassachusetts General HospitalRan2009 to 2012Enrolled90ConditionsPre-diabetes, Overweight, Metabolic SyndromeArmsDiabetes Genetic Counseling, No genetic counseling
3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
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  4. Article
  5. Review
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  8. Article
  9. Article
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  14. Review
  15. Article
  16. Genomic counseling: next generation counseling.Journal of genetic counseling · 2014
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jessica L WaxlerDepartment of Pediatrics, Massachusetts General Hospital, Boston, USA.
Kelsey E O'Brien
Linda M Delahanty
James B Meigs
Jose C Florez
Elyse R Park
Barbara R Pober
Richard W Grant

Funding

Epidemiology of Precursors to Type 2 DiabetesK24DK080140 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2007 to 2016
$1.9M
Using Genetic Risk Information to Enhance Diabetes PreventionR21DK084527 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GRANT, RICHARD W · 2009 to 2010
$885k
NIDDK NIH HHS K24 DK080140NIDDK NIH HHS R21 DK084527NIDDK NIH HHS R21 DK84527
6 · The paper itself

Abstract

Advances in genetic epidemiology have increased understanding of common, polygenic preventable diseases such as type 2 diabetes. As genetic risk testing based on this knowledge moves into clinical practice, we propose that genetic counselors will need to expand their roles and adapt traditional counseling techniques for this new patient set. In this paper, we present a genetic counseling intervention developed for a clinical trial [Genetic Counseling/Lifestyle Change for Diabetes Prevention, ClinicalTrials.gov identifier: NCT01034319] designed to motivate behavioral changes for diabetes prevention. Seventy-two phenotypically high-risk participants received counseling that included their diabetes genetic risk score, general education about diabetes risk factors, and encouragement to participate in a diabetes prevention program. Using two validated genetic counseling scales, participants reported favorable perceived control and satisfaction with the counseling session. Our intervention represents one model for applying traditional genetic counseling principles to risk testing for polygenetic, preventable diseases, such as type 2 diabetes.

Indexed as

Genetic CounselingDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseHumans

Identifiers

PMID22302620
PMCPMC3829637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.