ReviewPediatric nephrology (Berlin, Germany)2012
Epigenetics and developmental programming of adult onset diseases.
Review in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Insights into the Mechanisms of Fetal Growth Restriction-Induced Programming of Hypertension.Integrated blood pressure control · 2021Review
- Effects of Prenatal Hypoxia on Nervous System Development and Related Diseases.Frontiers in neuroscience · 2021Review
- The Role of Early Programming and Early Nutrition on the Development and Progression of Celiac Disease: A Review.Nutrients · 2020Review
- Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease.Nature communications · 2019Article
- Long-term consequences of disrupting adenosine signaling during embryonic development.Molecular aspects of medicine · 2017Review
- Genome-wide DNA methylation at birth in relation to in utero arsenic exposure and the associated health in later life.Environmental health : a global access science source · 2017Article
- Article
- In Utero Caffeine Exposure Induces Transgenerational Effects on the Adult Heart.Scientific reports · 2016Article
- Early life obesity and chronic kidney disease in later life.Pediatric nephrology (Berlin, Germany) · 2015Review
- Pediatric Nephrology in Primary Care: The Forest for the Trees.Frontiers in public health · 2015Article
- Nephron number and its determinants in early life: a primer.Pediatric nephrology (Berlin, Germany) · 2014Review
- Early-life Exposure to Endocrine Disrupting Chemicals and Later-life Health Outcomes: An Epigenetic Bridge?Aging and disease · 2014Review
- Effect of low birth weight on women's health.Clinical therapeutics · 2014Review
- Epigenetics: a new way to look at kidney diseases.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Review
- Thirty-three years of progress: the International Workshops on Developmental Nephrology and the role of IPNA.Pediatric nephrology (Berlin, Germany) · 2014Article
- Jussara (Euterpe edulis Mart.) supplementation during pregnancy and lactation modulates the gene and protein expression of inflammation biomarkers induced by trans-fatty acids in the colon of offspring.Mediators of inflammation · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal perturbations or sub-optimal conditions during development are now recognized as contributing to the onset of many diseases manifesting in adulthood. This "developmental programming" of disease has been explored using animal models allowing insights into the potential mechanisms involved. Impaired renal development, resulting in a low nephron number, has been identified as a common outcome that is likely to contribute to the development of hypertension in the offspring as adults. Changes in other organs and systems, including the heart and the hypothalamic–pituitary–adrenal axis, have also been found. Evidence has recently emerged suggesting that epigenetic changes may occur as a result of developmental programming and result in permanent changes in the expression patterns of particular genes. Such epigenetic modifications may be responsible not only for an increased susceptibility to disease for an individual, but indirectly for the establishment of a disease state in a subsequent generation. Further research in this field, particularly examination as to whether epigenetic changes to genes affecting kidney development do occur, are essential to understanding the underlying mechanisms of developmental programming of disease.
Indexed as
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22302599What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.