ArticleCellular & molecular biology letters2012
Stress-free state of the red blood cell membrane and the deformation of its skeleton.
Article in Cellular & molecular biology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Review
- The stress-free state of human erythrocytes: Data-driven inference of a transferable RBC model.Biophysical journal · 2023Article
- Quantifying the influences of radiation therapy on deformability of human red blood cells by dual-beam optical tweezers.RSC advances · 2021Article
- Theoretical Bases for the Role of Red Blood Cell Shape in the Regulation of Its Volume.Frontiers in physiology · 2020Review
- High-throughput microsphiltration to assess red blood cell deformability and screen for malaria transmission-blocking drugs.Nature protocols · 2018Article
- Erythrocyte stiffness during morphological remodeling induced by carbon ion radiation.PloS one · 2014Article
- Continuum- and particle-based modeling of shapes and dynamics of red blood cells in health and disease.Soft matter · 2013Article
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Authors and funding
2 authors.
Funding
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Abstract
The response of a red blood cell (RBC) to deformation depends on its membrane, a composite of a lipid bilayer and a skeleton, which is a closed, two-dimensional network of spectrin tetramers as its bonds. The deformation of the skeleton and its lateral redistribution are studied in terms of the RBC resting state for a fixed geometry of the RBC, partially aspirated into a micropipette. The geometry of the RBC skeleton in its initial state is taken to be either two concentric circles, a references biconcave shape or a sphere. It is assumed that in its initial state the skeleton is distributed laterally in a homogeneous manner with its bonds either unstressed, presenting its stress-free state, or prestressed. The lateral distribution was calculated using a variational calculation. It was assumed that the spectrin tetramer bonds exhibit a linear elasticity. The results showed a significant effect of the initial skeleton geometry on its lateral distribution in the deformed state. The proposed model is used to analyze the measurements of skeleton extension ratios by the method of applying two modes of RBC micropipette aspiration.
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