ArticleMedical oncology (Northwood, London, England)2012
Correlation of LAPTM4B polymorphisms with gallbladder carcinoma susceptibility in Chinese patients.
Article in Medical oncology (Northwood, London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- LAPTM4B gene polymorphism augments the risk of cancer: Evidence from an updated meta-analysis.Journal of cellular and molecular medicine · 2018Pooled it
- LAPTM4B polymorphism increases susceptibility to multiple cancers in Chinese populations: a meta-analysis.BMC genetics · 2014Pooled it
- The role and regulatory mechanism of lysosome associated protein transmembrane 4β in tumors.Frontiers in oncology · 2025Review
- Serum LAPTM4B as a Potential Diagnostic and Prognostic Biomarker for Breast Cancer.BioMed research international · 2022Article
- AP4 positively regulates LAPTM4B to promote hepatocellular carcinoma growth and metastasis, while reducing chemotherapy sensitivity.Molecular oncology · 2018Article
- LAPTM4B*2 allele is associated with the development of papillary thyroid carcinoma in Chinese women.Oncology letters · 2017Article
- Review
- Association betweenMolecular & cellular oncology · 2016Article
- Article
- The relationship between LAPTM4B polymorphisms and cancer risk in Chinese Han population: a meta-analysis.SpringerPlus · 2015Article
- Association between LAPTM4B gene polymorphism and breast cancer susceptibility in an Iranian population.Medical oncology (Northwood, London, England) · 2014Article
- Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population.Medical oncology (Northwood, London, England) · 2013Article
- LAPTM4B allele *2 is a marker of poor prognosis following hepatic tumor resection for hepatocellular carcinoma.PloS one · 2012Article
- Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gallbladder carcinoma (GBC) is a malignancy with an extremely poor prognosis. In order to improve the survival rate, identification of new susceptibility risk factors is of importance. Here, we report findings on the novel cancer-related gene lysosomal protein transmembrane 4 beta (LAPTM4B) that has two alleles designated LAPTM4B*1 and LAPTM4B*2. Allele *1 differs from allele *2 in that it contains one copy of a 19-bp sequence, whereas this sequence is duplicated in exon 1 of allele *2. This study aimed to investigate the relationship of LAPTM4B allelic variation and GBC susceptibility. LAPTM4B genotype was analyzed in 155 healthy individuals and 91 GBC patients by PCR, and the genotypic distribution of LAPTM4B was analyzed with the chi-squared test. The frequency of allele *2 was 37.9 and 24.8% in the GBC and the control groups, respectively, representing a significant difference between these two groups (P<0.001). LAPTM4B allele *2 may be a risk factor associated with genetic susceptibility to GBC.
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