SynthesisDigestive diseases and sciences2012
Diabetes mellitus is an independent risk factor for colorectal cancer.
Synthesis in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- CARING (CAncer Risk and INsulin analoGues): the association of diabetes mellitus and cancer risk with focus on possible determinants - a systematic review and a meta-analysis.Current drug safety · 2013Pooled it
- Mechanism of AGEs-RAGE axis inhibition of ferroptosis in type 2 diabetic colon cancer by regulatory CEACAM1.Scientific reports · 2026Article
- Identification and Validation of a Macrophage Phagocytosis-Related Gene Signature for Prognostic Prediction in Colorectal Cancer (CRC).Current issues in molecular biology · 2025Article
- A Mendelian randomization study of type 2 diabetes and cancer risk in East Asians.Cancer cell international · 2025Article
- Effect of diabetes mellitus type 2 and sulfonylurea on colorectal cancer development: a case-control study.BMC gastroenterology · 2024Article
- Zinc intake, SLC30A8 rs3802177 polymorphism, and colorectal cancer risk in a Korean population: a case-control study.Journal of cancer research and clinical oncology · 2023Article
- Causes of Death After Colorectal Cancer Diagnosis: A Population-Based Study.Frontiers in oncology · 2021Article
- Short-Chain Fatty Acids: A Soldier Fighting Against Inflammation and Protecting From Tumorigenesis in People With Diabetes.Frontiers in immunology · 2020Review
- AGR2 silencing contributes to metformin-dependent sensitization of colorectal cancer cells to chemotherapy.Oncology letters · 2019Article
- Diabetes mellitus and cancer incidence: the Atherosclerosis Risk in Communities (ARIC) cohort study.Journal of diabetes and metabolic disorders · 2019Article
- Molecular evidence of field cancerization initiated by diabetes in colon cancer patients.Molecular oncology · 2019Article
- Risk factors for colorectal cancer significantly vary by anatomic site.BMJ open gastroenterology · 2019Article
- Colonic Cancer and Acromegaly.Frontiers in endocrinology · 2019Review
- Utilization of Colorectal Cancer Screening among Saudi Elderly Population: A Study from the Saudi National Survey for Elderly HealthAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Type 2 diabetes and risk of colorectal cancer in two large U.S. prospective cohorts.British journal of cancer · 2018Article
- Racial-Ethnic Disparities in Late-Stage Colorectal Cancer Among Hispanics and Non-Hispanic Whites of New Mexico.Hispanic health care international : the official journal of the National Association of Hispanic Nurses · 2017Article
- Differences in risk factors of malignancy between men and women with type 2 diabetes: A retrospective case-control study.Oncotarget · 2017Article
- Diabetes as a risk factor of hospitalization in the surgical ward due to cancer in the elderly and middle-aged population.Archives of medical science : AMS · 2017Article
- Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer?Journal of diabetes and its complications · 2017Review
- Diabetes-induced mechanophysiological changes in the small intestine and colon.World journal of diabetes · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological studies have suggested positive associations between diabetes and colorectal cancer. However, the findings were inconsistent, especially regarding specific sex or cancer subsite.
aimsTo conduct a systematic review with meta-analysis to examine the association of diabetes mellitus with risk of colorectal cancer and to investigate whether the association is dependent on sex, cancer subsite, race/ethnicity, or duration of diabetes.
methodsRelevant studies were identified by searching Pubmed to May 12, 2011. The reference lists of identified articles were also reviewed. Two authors independently selected the studies and extracted relevant data. The study quality was assessed.
resultsThirty-nine studies (28 cohort studies and 11 case-control studies) were included in the final analysis. Compared with non-diabetic subjects, the pooled risk estimate of colorectal cancer for diabetic subjects was 1.29 (95% CI = 1.23-1.35). The subgroup analyses revealed that the risk was significantly increased for both genders, for every cancer subsite, and for both short duration and long duration of diabetes. Exposure to diabetes increased the risk of colorectal cancer for White and Asian, whereas there was no evidence of such an association either among Black or native Hawaiians.
conclusionsOur results confirmed that subjects with diabetes are at modestly increased risk of developing colorectal cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.