ReviewInternational orthopaedics2012
Optimal mechanical environment of the healing bone fracture/osteotomy.
Review in International orthopaedics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- In Silico possibilities to understand peri-implant bone healing- state of the Art.International journal of implant dentistry · 2025Review
- Effects of Peripheral Magnetic Stimulation on Bone Healing After Fractures in Mice.Calcified tissue international · 2025Article
- Non-screw glenoid augmentation constructs for shoulder instability with bone loss: A biomechanical assessment of static and elastic cerclage constructs.Journal of orthopaedics · 2025Article
- Immediate weight bearing as tolerated versus delayed weight bearing following intramedullary fixation for geriatric intertrochanteric fractures: a post hoc analysis.BMC musculoskeletal disorders · 2024Article
- The influence of immobility on muscle loss in older people with frailty and fragility fractures.GeroScience · 2024Article
- Review
- Article
- Two-Stage Lumbar Dynamic Stabilization Surgery: A Comprehensive Analysis of Screw Loosening Rates and Functional Outcomes Compared to Single-Stage Approach in Osteopenic and Osteoporotic Patients.Diagnostics (Basel, Switzerland) · 2024Article
- Biomechanical analysis of combi-hole locking compression plate during fracture healing: A numerical study of screw configuration.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2024Article
- A Systematic Review of Screw and Suture Button Glenoid Augmentation Constructs.Orthopaedic journal of sports medicine · 2023Review
- Analysis of bone stress and primary stability of a dental implant using strain and torque measurements.The Saudi dental journal · 2023Article
- Harnessing mechanical cues in the cellular microenvironment for bone regeneration.Frontiers in physiology · 2023Review
- An assessment of the fixin tplo jig to generate effective compression using a transverse fracture model.PloS one · 2023Article
- Article
- Aseptic femoral nonunion treated with exchange locked nailing with intramedullary augmentation cancellous bone graft.Journal of orthopaedic surgery and research · 2022Article
- Evaluation of Stress Distribution during Insertion of Tapered Dental Implants in Various Osteotomy Techniques: Three-Dimensional Finite Element Study.Materials (Basel, Switzerland) · 2021Article
- Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation.Bioelectricity · 2021Review
- Expert Consensus on the Contraindications and Cautions of Foam Rolling-An International Delphi Study.Journal of clinical medicine · 2021Article
- Magnetoelectric effect: principles and applications in biology and medicine- a review.Materials today. Bio · 2021Review
- Optimal management of older people with frailty non-weight bearing after lower limb fracture: a scoping review.Age and ageing · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this paper is to review recent experimental and clinical publications on bone biology with respect to the optimal mechanical environment in the healing process of fractures and osteotomies. The basic postulates of bone fracture healing include static bone compression and immobilisation/ fixation for three weeks and intermittent dynamic loading treatment afterwards. The optimal mechanical strain should be in the range of 100-2,000 microstrain, depending on the frequency of the strain application, type of bone and location in the bone, age and hormonal status. Higher frequency of mechanical strain application or larger number of repetition cycles result in increased bone mass at the healing fracture site, but only up to a certain limit, values beyond which no additional benefit is observed. Strain application and transition period from non-load-bearing to full load-bearing can be modified by implants allowing dynamisation of compression and generating strains at the fracture healing site in a controlled manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.