ArticleNucleic acids research2012
A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA methylation.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pearl millet response to drought: A review.Frontiers in plant science · 2023Pooled it
- Factor of DNA methylation 1 affects woodland strawberry plant stature and organ size via DNA methylation.Plant physiology · 2023Article
- A diRNA-protein scaffold module mediates SMC5/6 recruitment in plant DNA repair.The Plant cell · 2022Article
- FDDM1 and FDDM2, Two SGS3-like Proteins, Function as a Complex to Affect DNA Methylation in Arabidopsis.Genes · 2022Article
- RNAi activation with homologous and heterologous sequences that induce resistance against the begomovirus3 Biotech · 2021Article
- Arabidopsis C-terminal binding protein ANGUSTIFOLIA modulates transcriptional co-regulation of MYB46 and WRKY33.The New phytologist · 2020Article
- Identification of functional single nucleotide polymorphism ofPlant direct · 2020Article
- A 5-Enolpyruvylshikimate 3-Phosphate Synthase Functions as a Transcriptional Repressor inThe Plant cell · 2018Article
- Article
- KETCH1 imports HYL1 to nucleus for miRNA biogenesis inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- IDN2 Interacts with RPA and Facilitates DNA Double-Strand Break Repair by Homologous Recombination in Arabidopsis.The Plant cell · 2017Article
- AtMBD6, a methyl CpG binding domain protein, maintains gene silencing in Arabidopsis by interacting with RNA binding proteins.Journal of biosciences · 2017Article
- The RNAs of RNA-directed DNA methylation.Biochimica et biophysica acta. Gene regulatory mechanisms · 2017Review
- siRNA-directed DNA Methylation in Plants.Current genomics · 2015Article
- SNF2 chromatin remodeler-family proteins FRG1 and -2 are required for RNA-directed DNA methylation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Genome-wide analysis of leafbladeless1-regulated and phased small RNAs underscores the importance of the TAS3 ta-siRNA pathway to maize development.PLoS genetics · 2014Article
- SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis.Cell research · 2014Article
- RNA-directed DNA methylation requires stepwise binding of silencing factors to long non-coding RNA.The Plant journal : for cell and molecular biology · 2014Article
- RNA-directed DNA methylation: an epigenetic pathway of increasing complexity.Nature reviews. Genetics · 2014Review
- Methylation protects microRNAs from an AGO1-associated activity that uridylates 5' RNA fragments generated by AGO1 cleavage.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant specific SGS3-like proteins are composed of various combinations of an RNA-binding XS domain, a zinc-finger zf-XS domain, a coil-coil domain and a domain of unknown function called XH. In addition to being involved in de novo 2 (IDN2) and SGS3, the Arabidopsis genome encodes 12 uncharacterized SGS3-like proteins. Here, we show that a group of SGS3-like proteins act redundantly in RNA-directed DNA methylation (RdDM) pathway in Arabidopsis. Transcriptome co-expression analyses reveal significantly correlated expression of two SGS3-like proteins, factor of DNA methylation 1 (FDM1) and FDM2 with known genes required for RdDM. The fdm1 and fdm2 double mutations but not the fdm1 or fdm2 single mutations significantly impair DNA methylation at RdDM loci, release transcriptional gene silencing and dramatically reduce the abundance of siRNAs originated from high copy number repeats or transposons. Like IDN2 and SGS3, FDM1 binds dsRNAs with 5' overhangs. Double mutant analyses also reveal that IDN2 and three uncharacterized SGS3-like proteins FDM3, FDM4 and FDM5 have overlapping function with FDM1 in RdDM. Five FDM proteins and IDN2 define a group of SGS3-like proteins that possess all four-signature motifs in Arabidopsis. Thus, our results demonstrate that this group of SGS3-like proteins is an important component of RdDM. This study further enhances our understanding of the SGS3 gene family and the RdDM pathway.
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