Cbl exposes its RING finger.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed.

1. Zooming into the structure-function of RING finger proteins for anti-cancer therapeutic applications.American journal of cancer research · 2023
   Review
2. Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells.Scientific reports · 2020
   Article
3. Overexpression of Cancer Upregulated Gene 2 (CUG2) Decreases Spry2 Through c-Cbl, Leading to Activation of EGFR and β-Catenin Signaling.Cancer management and research · 2020
   Article
4. Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.The Journal of biological chemistry · 2017
   Article
5. Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015
   Review
6. Activation of the E3 ubiquitin ligase Parkin.Biochemical Society transactions · 2015
   Review
7. Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis.The international journal of biochemistry & cell biology · 2014
   Article
8. Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.PLoS computational biology · 2014
   Article
9. Physicochemical mechanisms of protein regulation by phosphorylation.Frontiers in genetics · 2014
   Review
10. Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis.Blood · 2013
    Article
11. E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.Cell death & disease · 2013
    Review
12. Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases.Biochimica et biophysica acta · 2013
    Review
13. Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins.Biochemistry and analytical biochemistry : current research · 2012
    Article

Corrections and comments

• Comment on
  Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.2012

Authors and funding

3 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as