ReviewActa pharmacologica Sinica2012
Rare adipose disorders (RADs) masquerading as obesity.
Review in Acta pharmacologica Sinica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 103 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Intermittent Pneumatic Compression Therapy on Tissue Volume, Pain, and Quality of Life in Women Living With Lipedema
Proof of Concept, Randomized, Controlled, and Crossover Study, to Assess the Effectiveness of Two Types of Compression Garments (Flat vs Circular Knitted) in the Maintenance Treatment of Patients With Lipedema
The Reliability and Validity of the Turkish Version of the Lipedema Screening Questionnaire
Who cites it
103 citing papers in PubMed, 3 syntheses or guidelines pooled it, 236 citations in OpenAlex.
- Lipedema Diagnosis, Clinical Manifestations, and Therapeutics: A Systematic Review.International journal of dermatology · 2026Pooled it
- [Differential diagnostics of lipedema and lymphedema : A practical guideline].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Guideline
- [Differential diagnostics of lipedema and lymphedema : A practical guideline].Zeitschrift fur Rheumatologie · 2018Guideline
- An abnormal lymphatic phenotype is associated with subcutaneous adipose tissue deposits in Dercum's disease.Obesity (Silver Spring, Md.) · 2014Trial
- Pain Reduction Following Liposuction for Lower Limb Lipedema: A Systematic Review and Meta-analysis.Aesthetic plastic surgery · 2026Article
- Lipoedema and Obesity Misclassification: A Phenotype Based Approach to Cardiometabolic Risk Beyond Body Mass Index.Clinical obesity · 2026Review
- Upper-Extremity Lipedema: Effects of Liposuction on Shoulder Mobility and Function.Aesthetic plastic surgery · 2026Article
- GLP-1 and GLP-1/GIP receptor agonist medication use and self-reported outcomes in individuals with lipedema: Results from a large online survey.Obesity pillars · 2026Article
- Article
- Validation and reliability of the Turkish version of the lipedema screening questionnaire.Turkish journal of physical medicine and rehabilitation · 2026Article
- Moderate weight loss decreases lipedema-affected body fat mass in a woman who is lean with lipedema.JCEM case reports · 2026Article
- Lipedema and Dynapenia: Inflammatory Myosteatosis as a Mechanistic Link Between Tissue Expansion and Muscle Dysfunction.International journal of molecular sciences · 2026Review
- Article
- Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam.Nature communications · 2026Article
- The lipedema common case report form as a research tool: standardizing lipedema data collection.Frontiers in global women's health · 2026Article
- The role of extracellular vesicles in the context of (inter-)cellular communication contributing to adipose tissue dysfunction in lipedema.Frontiers in cell and developmental biology · 2026Review
- Lipedema Reduction Surgery Outcomes and Comorbidities: A Retrospective Study.Plastic and reconstructive surgery. Global open · 2026Article
- Vascular changes and their implications in lipedema.Frontiers in cell and developmental biology · 2026Review
- Gestrinone, lipedema, and the limits of theoretical extrapolation in clinical practice: a critical narrative review.Jornal vascular brasileiro · 2026Review
- Giant nonencapsulated pubic lipoma: a case report and literature review on differential diagnoses of atypical lipomas.Case reports in plastic surgery & hand surgery · 2026Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Rare adipose disorders (RADs) including multiple symmetric lipomatosis (MSL), lipedema and Dercum's disease (DD) may be misdiagnosed as obesity. Lifestyle changes, such as reduced caloric intake and increased physical activity are standard care for obesity. Although lifestyle changes and bariatric surgery work effectively for the obesity component of RADs, these treatments do not routinely reduce the abnormal subcutaneous adipose tissue (SAT) of RADs. RAD SAT likely results from the growth of a brown stem cell population with secondary lymphatic dysfunction in MSL, or by primary vascular and lymphatic dysfunction in lipedema and DD. People with RADs do not lose SAT from caloric limitation and increased energy expenditure alone. In order to improve recognition of RADs apart from obesity, the diagnostic criteria, histology and pathophysiology of RADs are presented and contrasted to familial partial lipodystrophies, acquired partial lipodystrophies and obesity with which they may be confused. Treatment recommendations focus on evidence-based data and include lymphatic decongestive therapy, medications and supplements that support loss of RAD SAT. Associated RAD conditions including depression, anxiety and pain will improve as healthcare providers learn to identify and adopt alternative treatment regimens for the abnormal SAT component of RADs. Effective dietary and exercise regimens are needed in RAD populations to improve quality of life and construct advanced treatment regimens for future generations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.