Evidence map›Paper›PMID 22301528›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2012

Nasal intermittent positive pressure ventilation after surfactant treatment for respiratory distress syndrome in preterm infants <30 weeks' gestation: a randomized, controlled trial.

R Ramanathan, K C Sekar, M Rasmussen, J Bhatia, R F Soll

Erratum issued 2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 42 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 5 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03347136 nacompletednot on this mapstarted 2015, after this paper: background citation

Comparison of CPAP and NIPPV as a Mode of Non-invasive Respiratory Support for Neonates in a Level III NICU

TypeinterventionalSponsorMinistry of Health, Sri LankaRan2015 to 2015Enrolled80ConditionsRespiratory Distress of NewbornArmsCPAP, NIPPV
NCT03548324 nacompletednot on this mapstarted 2019, after this paper: background citation

Enteral Nutrition Tolerance and Non-invasive Respiratory Support in Preterm Infants

TypeinterventionalSponsorUniversity of Turin, ItalyRan2019 to 2021Enrolled280ConditionsVery Low Birth Weight Infant, Respiratory Distress Syndrome in Premature Infant, Enteral Feeding IntoleranceArmsHHHFNC, NCPAP
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 5 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
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  6. Trial
  7. Bubble NIPPV: Guidelines for Use.Children (Basel, Switzerland) · 2025
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  16. Practical aspects on the use of non-invasive respiratory support in preterm infants.International journal of pediatrics & adolescent medicine · 2020
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

R RamanathanUSC Division of Neonatal Medicine, LAC+USC Medical Center, Good Samaritan Hospital and Children's Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA, USA. ramanath@usc.edu
K C Sekar
M Rasmussen
J Bhatia
R F Soll
Augusta University Health · USKeck Hospital of USC · USSharp Mary Birch Hospital for Women & Newborns · USUniversity of Oklahoma Health Sciences Center · USUniversity of Vermont · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the effect of early extubation to nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) on the need for mechanical ventilation via endotracheal tube (MVET) at 7 days of age in preterm infants <30 weeks' gestation requiring intubation and surfactant for respiratory distress syndrome (RDS) within 60  min of delivery. STUDY

designMulticenter, randomized, controlled trial. A total of 57 infants were randomized within 120  min of birth to NCPAP (BW 1099 g and GA 27.8 weeks) and 53 infants to NIPPV (BW 1052  g, and GA 27.8 weeks). Infants were stabilized on NCPAP at birth and were given poractant alfa combined with MVET within 60  min of age. When stabilized on MVET, they were extubated within the next hours or days to NCPAP or NIPPV.

resultA total of 42% [corrected] of infants needed MVET at 7 days of age in the NCPAP group compared with 17% in the NIPPV group (OR: 3.6; 95% CI: 1.5, 8.7). Days on MVET were 12 ± 11 days in NCPAP group compared with 7.5 ± 12 days in the NIPPV group (median 1 vs 7 days; P=0.006). Clinical bronchopulmonary dysplasia (BPD) was 39% in the NCPAP group compared to 21% in the NIPPV group (OR: 2.4; 95% CI: 1.02, 5.6). Physiological BPD was 46% in the NCPAP group compared with 11% in the NIPPV group (OR: 6.6, 95% CI: 2.4, 17.8; P=0.001). There were no differences in any other outcomes between the two groups.

conclusionNIPPV compared with NCPAP reduced the need for MVET in the first week, duration of MVET, and clinical as well as physiological BPD in preterm infants receiving early surfactant for RDS.

Indexed as

Infant, PrematureContinuous Positive Airway PressureFemaleFollow-Up StudiesGestational AgeHumansInfant, NewbornIntermittent Positive-Pressure VentilationIntubation, IntratrachealMalePregnancyProspective StudiesPulmonary SurfactantsRespiration, ArtificialRespiratory Distress Syndrome, NewbornRisk AssessmentPulmonary Surfactants

Identifiers

PMID22301528
OpenAlexW2087656152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.