Evidence map›Paper›PMID 22301479›Full record

ArticleThe Pediatric infectious disease journal2012

Therapeutic monitoring of voriconazole in children less than three years of age: a case report and summary of voriconazole concentrations for ten children.

Elizabeth H Doby, Daniel K Benjamin, Anne J Blaschke, Robert M Ward, Andrew T Pavia, Paul L Martin, Timothy A Driscoll, Michael Cohen-Wolkowiez, Cassandra Moran

Abstract readCase Reports
In one paragraph

Article in The Pediatric infectious disease journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Characterization of Therapeutic Drug Monitoring Practices of Voriconazole and Posaconazole at a Pediatric Hospital.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021
    Article
  7. Invasive Aspergillosis in Children: Update on Current Guidelines.Mediterranean journal of hematology and infectious diseases · 2018
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Elizabeth H DobyDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Daniel K Benjamin
Anne J Blaschke
Robert M Ward
Andrew T Pavia
Paul L Martin
Timothy A Driscoll
Michael Cohen-Wolkowiez
Cassandra Moran
Duke University · USUniversity of Utah · US

Funding

Pilot Project for the DTMI CRA ProgramUL1RR024128 · NCRR · DUKE UNIVERSITY · PI CALIFF, ROBERT M · 2006 to 2010
$48.1M
UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
HT-Film-Array: a system to assess respiratory viruses with emphasis on influenzaU01AI074419 · NIAID · BIOFIRE DEFENSE, LLC. · PI PORITZ, MARK AARON · 2007 to 2011
$8.2M
An Automated Multi-target Diagnostic System for Gastrointestinal PathogensR01AI089489 · NIAID · BIOFIRE DEFENSE, LLC. · PI ROGATCHEVA, MARGARITA B · 2010 to 2012
$3.3M
FilmArray Biothreat Pathogens: An Automated Multiplex PCR Diagnostic SystemU01AI082184 · NIAID · BIOFIRE DEFENSE, LLC. · PI OTA, IRENE M · 2009 to 2010
$3.0M
Prevention of Invasive Candidiasis: PK, Safety, and Neurodevelopmental OutcomesR01HD057956 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2008 to 2012
$2.8M
P450 Metabolism of Glucocorticoids in Lungs of Pediatric AsthmaticsR01HD060559 · NICHD · UNIVERSITY OF UTAH · PI REILLY, CHRISTOPHER A · 2010 to 2014
$2.3M
North Carolina Collaborative PPRU NetworkU10HD045962 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2004 to 2009
$2.1M
Prevention of Invasive Candidiasis: PK, Safety, and Neurodevelopmental OutcomesR01FD003519 · FDA · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2008 to 2011
$1.6M
Epidemiology and Etiology of Hospitalized Pneumonia in ChildrenU18IP000303 · IP · UNIVERSITY OF UTAH · PI AMPOFO, KROW · 2009 to 2010
$1.6M
Mentorship of early-career pediatricians in quantitiative methods and therapeuticK24HD058735 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2009 to 2018
$1.5M
Rapid Molecular Testing for Neonatal Antibiotic-Resistant PathogensK23AI079401 · NIAID · UNIVERSITY OF UTAH · PI BLASCHKE, ANNE J. · 2009 to 2012
$549k
FDA HHS 1R01FD003519-01FDA HHS R01 FD003519NCIRD CDC HHS 1U18IP000303-01NCIRD CDC HHS U18 IP000303NCRR NIH HHS 1UL 1RR024128-01NCRR NIH HHS 3UL1RR025764-02S3NCRR NIH HHS UL1 RR024128NCRR NIH HHS UL1 RR025764NIAID NIH HHS 1K23AI079401NIAID NIH HHS 1R01AI089489-01NIAID NIH HHS 1U01AI082184-01NIAID NIH HHS K23 AI079401NIAID NIH HHS R01 AI089489NIAID NIH HHS U01 AI074419NIAID NIH HHS U01 AI082184NIAID NIH HHS U01-AI74419NICHD NIH HHS 1K23HD064814-01NICHD NIH HHS 1K24HD058735-01NICHD NIH HHS 1R01HD057956-02NICHD NIH HHS 1U10-HD45962-06NICHD NIH HHS HD060559-01NICHD NIH HHS HHSN267200700051CNICHD NIH HHS K23 HD064814NICHD NIH HHS K24 HD058735NICHD NIH HHS R01 HD057956NICHD NIH HHS R01 HD060559NICHD NIH HHS R01 HD060559-02NICHD NIH HHS U10 HD045962NIDDK NIH HHS HHSN267200700051CPHS HHS 1U181P000303
6 · The paper itself

Abstract

Voriconazole is the treatment of choice for invasive aspergillosis and its use is increasing in pediatrics. Minimal pharmacokinetic data exist in young children. We report voriconazole concentrations for 10 children <3 years of age and pharmacokinetic parameters for 1 infant who had therapeutic drug monitoring performed. Trough concentrations were unpredictable based on dose, highlighting the need to follow values during therapy.

Indexed as

Drug MonitoringAntifungal AgentsChild, PreschoolFemaleHumansInfantInvasive Pulmonary AspergillosisMalePlasmaPyrimidinesTriazolesVoriconazoleAntifungal AgentsPyrimidinesTriazolesVoriconazole

Identifiers

PMID22301479
PMCPMC3356483
OpenAlexW2071304970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.