ArticleAIDS (London, England)2012
Elevated cytokine and chemokine levels in the placenta are associated with in-utero HIV-1 mother-to-child transmission.
Article in AIDS (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Compartment-specific soluble immune profiles associated with preterm birth, perinatal death, and low birthweight in pregnant individuals living with HIV.bioRxiv : the preprint server for biology · 2026Article
- Dynamics of Cytokines and Chemokines During the Peripartum Period in People Living With Human Immunodeficiency Virus.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Observational
- Distinct cytokine profiles in late pregnancy in Ugandan people with HIV.Scientific reports · 2024Article
- Associations of circulation levels of cytokines with birthweight, preterm birth, spontaneous miscarriages, and stillbirth: A Mendelian randomization analysis.Frontiers in genetics · 2023Article
- Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure.Frontiers in immunology · 2021Review
- The impact of the duration of HAART on cytokine profiles in pregnancy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- HIV, Cytomegalovirus, and Malaria Infections during Pregnancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan Neonates.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Impact of maternal HIV infection on pregnancy outcomes in southwestern China - a hospital registry based study.Epidemiology and infection · 2019Article
- Pediatric HIV-1 Acquisition and Lifelong Consequences of Infant Infection.Current immunology reviews · 2019Article
- Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques.Journal of virology · 2018Article
- High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+ T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control.Frontiers in immunology · 2018Article
- Host Molecular Factors and Viral Genotypes in the Mother-to-Child HIV-1 Transmission in Sub-Saharan Africa.Journal of public health in Africa · 2017Review
- Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health.Seminars in immunopathology · 2016Review
- The Significance of Interferon-γ in HIV-1 Pathogenesis, Therapy, and Prophylaxis.Frontiers in immunology · 2014Review
- Severity of maternal HIV-1 disease is associated with adverse birth outcomes in Malawian women: a cohort study.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Immunology of pediatric HIV infection.Immunological reviews · 2013Review
- Role of the placenta in adverse perinatal outcomes among HIV-1 seropositive women.Journal of Nippon Medical School = Nippon Ika Daigaku zasshi · 2013Review
- Imbalance of placental regulatory T cell and Th17 cell population dynamics in the FIV-infected pregnant cat.Virology journal · 2012Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo determine whether there is an association between cytokine and chemokine levels in plasma isolated from the placenta and HIV-1 mother-to-child transmission (MTCT).
designWe designed a case-control study of HIV-infected, pregnant women enrolled in the Malaria and HIV in Pregnancy cohort. Participants were recruited in Blantyre, Malawi, from 2000 to 2004. Patients were women whose children were HIV-1 DNA-positive at birth (in-utero MTCT) or HIV-1 DNA-negative at birth and HIV-1 DNA-positive at 6 weeks postpartum (intrapartum MTCT); controls were women whose children were HIV-1 DNA-negative both at birth and 6 weeks postpartum.
methodsAfter delivery, blood was isolated from an incision on the basal plate of the placenta. We used a Bio-Plex human cytokine assay (Bio-Rad, Hercules, California USA) to simultaneously quantify 27 cytokines, chemokines and growth factors in placental plasma. HIV-1 RNA copies were quantified with the Roche Amplicor kit.
resultsLevels of interleukin (IL) 4, IL-5, IL-6, IL-7, IL-9, eotaxin, IL-1Ra and interferon gamma-induced protein 10 (IP-10) were significantly elevated in placental plasma isolated from cases of in-utero HIV-1 MTCT. In contrast, only granulocyte colony-stimulating factor was elevated in placental plasma isolated from cases of intrapartum MTCT. After adjusting for maternal age, gestational age and peripheral CD4(+) T-cell count, every log(10) increase in placental IP-10 was associated with a three-fold increase in the prevalence of in-utero HIV-1 MTCT.
conclusionElevated cytokine and chemokine levels in placental plasma were associated with in-utero and not intrapartum MTCT. IP-10, which is both a T-cell chemokine and potentiator of HIV-replication, was robustly and independently associated with prevalent, in-utero MTCT.
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