ArticleGastrointestinal endoscopy2012
Injectable drug-eluting elastomeric polymer: a novel submucosal injection material.
Article in Gastrointestinal endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Gastric endoscopic submucosal dissection using sodium carboxymethylcellulose as a new injection substance.Fukushima journal of medical science · 2016Trial
- Advancements in injection materials for submucosal lifting in endoscopic interventions.World journal of gastrointestinal surgery · 2025Review
- Endoscopically injectable and self-crosslinkable hydrogel-mediated stem cell transplantation for alleviating esophageal stricture after endoscopic submucosal dissection.Bioengineering & translational medicine · 2023Article
- A review of hydrogels used in endoscopic submucosal dissection for intraoperative submucosal cushions and postoperative management.Regenerative biomaterials · 2023Review
- Nanodrugs systems for therapy and diagnosis of esophageal cancer.Frontiers in bioengineering and biotechnology · 2023Review
- Development of Biodegradable Osteopromotive Citrate-Based Bone Putty.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Phototherapy and optical waveguides for the treatment of infection.Advanced drug delivery reviews · 2021Review
- Off-label use of 0.4 % sodium hyaluronate teardrops: a safe and effective solution for submucosal injection in gastric endoscopic submucosal dissection.Endoscopy international open · 2020Article
- Cellulose nanofiber dispersion as a new submucosal injection material for endoscopic treatment: preliminary experimental study.Endoscopy international open · 2020Article
- Evaluation of EleviewPolymers · 2020Article
- A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance.Journal of visualized experiments : JoVE · 2018Article
- Citrate chemistry and biology for biomaterials design.Biomaterials · 2018Review
- Design Strategies and Applications of Biomaterials and Devices for Hernia Repair.Bioactive materials · 2016Article
- Endoscopic submucosal dissection and its potential role in the management of early colorectal neoplasia in UK.Frontline gastroenterology · 2016Article
- Solutions for submucosal injection in endoscopic resection: a systematic review and meta-analysis.Endoscopy international open · 2016Article
- Citrate-Based Biomaterials and Their Applications in Regenerative Engineering.Annual review of materials research · 2015Article
- Rebamipide delivered by brushite cement enhances osteoblast and macrophage proliferation.PloS one · 2015Article
- Endoscopic Submucosal Dissection (ESD) in Colorectal Tumors.Viszeralmedizin · 2014Review
- Improved Techniques for Endoscopic Mucosal Resection (EMR) in Colorectal Adenoma.Viszeralmedizin · 2014Review
- New progress in endoscopic treatment of esophageal diseases.World journal of gastroenterology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBiodegradable hydrogels can deliver therapeutic payloads with great potentials in EMR and endoscopic submucosal dissection (ESD) to yield improvements in efficacy and foster mucosal regeneration.
objectiveTo assess the efficacy of an injectable drug-eluting elastomeric polymer (iDEEP) as a submucosal injection material.
designComparative study of 3 different solutions by using material characterization tests and ex vivo and in vivo porcine models.
settingAcademic hospital.
interventionsThirty gastric submucosal cushions were achieved with saline solution (0.9%), sodium hyaluronate (0.4%), and iDEEP (n = 10) in ex vivo porcine stomachs. Four porcine gastric submucosal cushions were then created in vivo by using iDEEP. MAIN OUTCOME MEASUREMENTS: Maximum injection pressure, rebamipide release rate, submucosal elevation duration, and assessment of in vivo efficacy by en bloc resection.
resultsNo significant difference in injection pressures between iDEEP (28.9 ± 0.3 psi) and sodium hyaluronate (29.5 ± 0.4 psi, P > .05) was observed. iDEEP gels displayed a controlled release of rebamipide up to 2 weeks in vitro. The elevation height of iDEEP (5.7 ± 0.5 mm) was higher than that of saline solution (2.8 ± 0.2 mm, P < .01) and sodium hyaluronate (4.2 ± 0.2 mm, P < .05). All EMR procedures were successfully performed after injection of iDEEP, and a large gel cushion was noted after the resection procedure. LIMITATIONS: Benchtop, ex vivo, and nonsurvival pig study.
conclusionsA novel injection solution was evaluated for endoscopic resection. These results suggest that iDEEP may provide a significant step toward the realization of an ideal EMR and endoscopic submucosal dissection injection material.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.