Evidence map›Paper›PMID 22301133›Full record

ArticleGenome research2012

Translating cancer 'omics' to improved outcomes.

Emily A Vucic, Kelsie L Thu, Keith Robison, Leszek A Rybaczyk, Raj Chari, Carlos E Alvarez, Wan L Lam

Abstract read
In one paragraph

Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Prostate cancer in omics era.Cancer cell international · 2022
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Insight updating of the molecular hallmarks in ovarian carcinoma.EJC supplements : EJC : official journal of EORTC, European Organization for Research and Treatment of Cancer ... [et al.] · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emily A VucicBritish Columbia Cancer Research Centre, Vancouver V5Z 1L3, Canada. evucic@bccrc.ca
Kelsie L Thu
Keith Robison
Leszek A Rybaczyk
Raj Chari
Carlos E Alvarez
Wan L Lam

Funding

Whole genome array CGH of progressing oral dysplasiaR01DE015965 · NIDCR · BRITISH COLUMBIA CANCER AGENCY · PI LAM, WAN L · 2004 to 2007
$1.1M
DNA Copy Number Variation in DogsR21HG004663 · NHGRI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI ALVAREZ, CARLOS E. · 2009 to 2010
$396k
CIHR MOP-110949CIHR MOP 86731CIHR MOP 94867NHGRI NIH HHS HG004663NHGRI NIH HHS R21 HG004663NIDCR NIH HHS R01 DE015965
6 · The paper itself

Abstract

The genomics era has yielded great advances in the understanding of cancer biology. At the same time, the immense complexity of the cancer genome has been revealed, as well as a striking heterogeneity at the whole-genome (or omics) level that exists between even histologically similar tumors. The vast accrual and public availability of multi-omics databases with associated clinical annotation including tumor histology, patient response, and outcome are a rich resource that has the potential to lead to rapid translation of high-throughput omics to improved overall survival. We focus on the unique advantages of a multidimensional approach to genomic analysis in this new high-throughput omics age and discuss the implications of the changing cancer demographic to translational omics research.

Indexed as

GenomicsProteomicsTranslational Research, BiomedicalAnimalsBiomarkers, TumorDisease Models, AnimalEarly Detection of CancerGenetic Association StudiesHumansMolecular Targeted TherapyMutationNeoplasmsPrognosisSignal TransductionBiomarkers, Tumor

Identifiers

PMID22301133
PMCPMC3266027

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.