ArticlePlant physiology2012
Constitutive activation of transcription factor OsbZIP46 improves drought tolerance in rice.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.
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151 citing papers in PubMed, 421 citations in OpenAlex.
- Maize ZmbZIP92 transcription factor positively regulates drought tolerance inPlant signaling & behavior · 2026Article
- Natural variation inScience advances · 2026Article
- Genome-wide identification and expression analysis of RBR-type ubiquitin ligase family genes reveal the role of ZmIBR10 in maize disease resistance.BMC plant biology · 2026Article
- OsbZIP35 Mediates ABA-Dependent Drought Tolerance and Stress-Responsive Yield Maintenance in Rice.Rice (New York, N.Y.) · 2026Article
- Genome-wide association study of alkali tolerance at germination stage in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Stress-tolerance genes in rice: bridging gene discovery, functional validation, and breeding applications.Frontiers in plant science · 2026Review
- Molecular evolution of the bZIP family in allotetraploid Gossypium and GhbZIP017 function under drought stress.Plant cell reports · 2025Article
- CRISPR/Cas9-Mediated Knockout ofInternational journal of molecular sciences · 2025Article
- Genome-Wide identification and expression analysis of CsABF/AREB gene family in cucumber (Cucumis sativus L.) and in response to phytohormonal and abiotic stresses.Scientific reports · 2025Article
- Review
- OsCactin positively regulates the drought stress response in rice.Plant cell reports · 2024Article
- Stress-Inducible Expression ofPlants (Basel, Switzerland) · 2024Article
- Profiling of Key Hub Genes Using a Two-State Weighted Gene Co-Expression Network of 'Jao Khao' Rice under Soil Salinity Stress Based on Time-Series Transcriptome Data.International journal of molecular sciences · 2024Article
- Drought-responsive dynamics of H3K9ac-marked 3D chromatin interactions are integrated by OsbZIP23-associated super-enhancer-like promoter regions in rice.Genome biology · 2024Article
- Expression of Foxtail MilletBiomolecules · 2024Article
- Identification of candidate genes controlling cold tolerance at the early seedling stage from Dongxiang wild rice by QTL mapping, BSA-Seq and RNA-Seq.BMC plant biology · 2024Article
- Histone deacetylase OsHDA716 represses rice chilling tolerance by deacetylating OsbZIP46 to reduce its transactivation function and protein stability.The Plant cell · 2024Article
- A transposon insertion in the promoter of OsUBC12 enhances cold tolerance during japonica rice germination.Nature communications · 2024Article
- Molecular Mechanisms and Regulatory Pathways Underlying Drought Stress Response in Rice.International journal of molecular sciences · 2024Review
- Genome-wide identification, characterization and expression analysis of theFrontiers in plant science · 2024Article
91 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OsbZIP46 is one member of the third subfamily of bZIP transcription factors in rice (Oryza sativa). It has high sequence similarity to ABA-responsive element binding factor (ABF/AREB) transcription factors ABI5 and OsbZIP23, two transcriptional activators positively regulating stress tolerance in Arabidopsis (Arabidopsis thaliana) and rice, respectively. Expression of OsbZIP46 was strongly induced by drought, heat, hydrogen peroxide, and abscisic acid (ABA) treatment; however, it was not induced by salt and cold stresses. Overexpression of the native OsbZIP46 gene increased ABA sensitivity but had no positive effect on drought resistance. The activation domain of OsbZIP46 was defined by a series of deletions, and a region (domain D) was identified as having a negative effect on the activation. We produced a constitutive active form of OsbZIP46 (OsbZIP46CA1) with a deletion of domain D. Overexpression of OsbZIP46CA1 in rice significantly increased tolerance to drought and osmotic stresses. Gene chip analysis of the two overexpressors (native OsbZIP46 and the constitutive active form OsbZIP46CA1) revealed that a large number of stress-related genes, many of them predicted to be downstream genes of ABF/AREBs, were activated in the OsbZIP46CA1 overexpressor but not (even down-regulated) in the OsbZIP46 overexpressor. OsbZIP46 can interact with homologs of SnRK2 protein kinases that phosphorylate ABFs in Arabidopsis. These results suggest that OsbZIP46 is a positive regulator of ABA signaling and drought stress tolerance of rice depending on its activation. The stress-related genes activated by OsbZIP46CA1 are largely different from those activated by the other rice ABF/AREB homologs (such as OsbZIP23), further implying the value of OsbZIP46CA1 in genetic engineering of drought tolerance.
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