ArticleCancer prevention research (Philadelphia, Pa.)2012
Epigenetic differences in normal colon mucosa of cancer patients suggest altered dietary metabolic pathways.
Article in Cancer prevention research (Philadelphia, Pa.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- The Epigenetic Overlap between Obesity and Mood Disorders: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- The examination of fatty acid taste with edible strips.Physiology & behavior · 2012Trial
- The Interplay among Wnt/β-catenin Family Members in Colorectal Adenomas and Surrounding Tissues.Biomedicines · 2024Article
- Epigenome-Wide Study Identifies Epigenetic Outliers in Normal Mucosa of Patients with Colorectal Cancer.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- Aberrant expression of MYD88 via RNA-controlling CNOT4 and EXOSC3 in colonic mucosa impacts generation of colonic cancer.Cancer science · 2021Article
- LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells.Bioscience reports · 2020Article
- RW-2018-Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health.JPEN. Journal of parenteral and enteral nutrition · 2019Review
- A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.Life science alliance · 2019Article
- Article
- Genome-wide DNA methylation profiling reveals cancer-associated changes within early colonic neoplasia.Oncogene · 2017Article
- Lipidome in colorectal cancer.Oncotarget · 2016Review
- Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells.The Journal of nutrition · 2016Article
- LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer.Oncotarget · 2015Article
- Causes of genome instability: the effect of low dose chemical exposures in modern society.Carcinogenesis · 2015Review
- Dysregulated serum response factor triggers formation of hepatocellular carcinoma.Hepatology (Baltimore, Md.) · 2015Article
- DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility.Clinical epigenetics · 2015Article
- Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Review
- Comparative Correlation Structure of Colon Cancer Locus Specific Methylation: Characterisation of Patient Profiles and Potential Markers across 3 Array-Based Datasets.Journal of Cancer · 2015Article
- DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer.Biochemical and biophysical research communications · 2014Review
- Validation of methylation biomarkers that distinguish normal colon mucosa of cancer patients from normal colon mucosa of patients without cancer.Cancer prevention research (Philadelphia, Pa.) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have compared DNA methylation in normal colon mucosa between patients with colon cancer and patients without cancer. We identified significant differences in methylation between the two groups at 114 to 874 genes. The majority of the differences are in pathways involved in the metabolism of carbohydrates, lipids, and amino acids. We also compared transcript levels of genes in the insulin signaling pathway. We found that the mucosa of patients with cancer had significantly higher transcript levels of several hormones regulating glucose metabolism and significantly lower transcript levels of a glycolytic enzyme and a key regulator of glucose and lipid homeostasis. These differences suggest that the normal colon mucosa of patients with cancer metabolizes dietary components differently than the colon mucosa of controls. Because the differences identified are present in morphologically normal tissue, they may be diagnostic of colon cancer and/or prognostic of colon cancer susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.