ArticleGenetic testing and molecular biomarkers2012
Haptoglobin 2-2 genotype is associated with increased risk of type 2 diabetes mellitus in northern Chinese.
Article in Genetic testing and molecular biomarkers, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Precision medicine approach to coronary artery disease: Haptoglobin phenotype‑guided risk assessment.Molecular medicine reports · 2026Article
- Clinical Association of Haptoglobin with Oxidized LDL in Obese Patients with Type 2 Diabetes Mellitus.Nutrients · 2025Article
- Haptoglobin Genotypes in Hidradenitis Suppurativa: Haptoglobin 2-2 Genotype Is Associated With Familial Hidradenitis Suppurativa and More Flares.International journal of dermatology · 2025Article
- Contribution of haptoglobin phenotypic variation to the presence of hyperhomocysteinemia in type 2 diabetics with and without angiopathy.European journal of clinical nutrition · 2025Article
- Article
- Association of haptoglobin and natural resistance-associated macrophage protein 1 alleles with heme-consuming periodontal pathogens in chronic periodontitis and peri-implantitis: A pilot study.Journal of advanced periodontology & implant dentistry · 2020Article
- Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis.JCI insight · 2019Observational
- Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients.Cardiovascular diabetology · 2018Article
- Increased Levels of Serum Protein Complexes Are Associated with Type 2 Diabetes.International journal of medical sciences · 2018Article
- Correlation of geographic distributions of haptoglobin alleles with prevalence of multiple sclerosis (MS) - a narrative literature review.Metabolic brain disease · 2017Review
- The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness.Diabetes & vascular disease research · 2016Article
- Combined association analysis of interleukin 1-receptor antagonist (IL-1RN) variable number of tandem repeat (VNTR) and Haptoglobin 1/2 polymorphisms with type 2 diabetes mellitus risk.Journal of diabetes and metabolic disorders · 2015Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the association between haptoglobin (Hp) gene polymorphism and occurrence of type 2 diabetes mellitus (T2DM) in a northern Chinese population. We studied the association of the Hp gene polymorphism with T2DM in 584 unrelated T2DM patients and 690 control subjects with normal glucose tolerance among northern Chinese. The patients were diagnosed in accordance with the guidelines of the American Diabetes Association. The clinical characteristics of the study population were recorded, and the Hp genotype was determined. The frequencies of the genotypes in the group of T2DM patients and the controls were as follows: Hp2-2, 51.7% and 44.1%; Hp2-1, 39.7% and 45.1%; and Hp1-1, 8.6% and 10.9%, respectively. There was significant difference for the genotypic and allelic distribution between the two groups (p=0.021 and p=0.007, respectively). Even after readjusting for the confounding effects of age, gender, and body mass index, a significant effect of genotypes on T2DM was still found in the recessive model for the Hp2 allele tested (p=0.002). Those who had the Hp2-2 genotype had a significantly higher risk for T2DM than those with other genotypes (odds ratio=1.441, 95% confidence interval=1.143-1.817). The results showed that the Hp2-2 genotype is associated with increased risk of T2DM in the northern Chinese Han population.
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