ArticleParticle and fibre toxicology2012
Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint.
Article in Particle and fibre toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 137 citations in OpenAlex.
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- Titanium Dioxide Induces Apoptosis under UVA Irradiation via the Generation of Lysosomal Membrane Permeabilization-Dependent Reactive Oxygen Species in HaCat Cells.Nanomaterials (Basel, Switzerland) · 2021Article
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- Titanium Dioxide Nanoparticles Induced HeLa Cell Necrosis under UVA Radiation through the ROS-mPTP Pathway.Nanomaterials (Basel, Switzerland) · 2020Article
- Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiOParticle and fibre toxicology · 2020Article
- Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties.Particle and fibre toxicology · 2020Article
- Fragmentation of polymer nanocomposites: modulation by dry and wet weathering, fractionation, and nanomaterial filler.Environmental science. Nano · 2020Article
- Genotoxicity assessment of titanium dioxide nanoparticle accumulation of 90 days in the liver ofGenes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020Article
- Amelioration of titanium dioxide nanoparticle reprotoxicity by the antioxidants morin and rutin.Environmental science and pollution research international · 2019Article
- Polypropylene-MWCNT composite degradation, release, detection, and toxicity of MWCNT during accelerated aging.Environmental science. Nano · 2019Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known of how the toxicity of nanoparticles is affected by the incorporation in complex matrices. We compared the toxic effects of the titanium dioxide nanoparticle UV-Titan L181 (NanoTiO2), pure or embedded in a paint matrix. We also compared the effects of the same paint with and without NanoTiO2.
methodsMice received a single intratracheal instillation of 18, 54 and 162 μg of NanoTiO2 or 54, 162 and 486 μg of the sanding dust from paint with and without NanoTiO2. DNA damage in broncheoalveolar lavage cells and liver, lung inflammation and liver histology were evaluated 1, 3 and 28 days after intratracheal instillation. Printex 90 was included as positive control.
resultsThere was no additive effect of adding NanoTiO2 to paints: Therefore the toxicity of NanoTiO2 was reduced by inclusion into a paint matrix. NanoTiO2 induced inflammation in mice with severity similar to Printex 90. The inflammatory response of NanoTiO2 and Printex 90 correlated with the instilled surface area. None of the materials, except of Printex 90, induced DNA damage in lung lining fluid cells. The highest dose of NanoTiO2 caused DNA damage in hepatic tissue 1 day after intratracheal instillation. Exposure of mice to the dust from paints with and without TiO2 was not associated with hepatic histopathological changes. Exposure to NanoTiO2 or to Printex 90 caused slight histopathological changes in the liver in some of the mice at different time points.
conclusionsPulmonary inflammation and DNA damage and hepatic histopathology were not changed in mice instilled with sanding dust from NanoTiO2 paint compared to paint without NanoTiO2. However, pure NanoTiO2 caused greater inflammation than NanoTiO2 embedded in the paint matrix.
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