ArticleJournal of biomedical science2012
Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome.
Article in Journal of biomedical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- DNA methylation patterns of LINE-1 and Alu for pre-symptomatic dementia in type 2 diabetes.PloS one · 2020Article
- Does the Presence of Transposable Elements Impact the Epigenetic Environment of Human Duplicated Genes?Genes · 2019Article
- Article
- Transposable elements: genome innovation, chromosome diversity, and centromere conflict.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Review
- The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements.Epigenetics & chromatin · 2016Article
- Platelet mitochondrial DNA methylation: a potential new marker of cardiovascular disease.Clinical epigenetics · 2015Article
- Effects of short-term exposure to inhalable particulate matter on DNA methylation of tandem repeats.Environmental and molecular mutagenesis · 2014Article
- Genome-wide identification and analysis of Japonica and Indica cultivar-preferred transcripts in rice using 983 Affymetrix array data.Rice (New York, N.Y.) · 2013Article
- Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants.Particle and fibre toxicology · 2013Article
- Effects of airborne pollutants on mitochondrial DNA methylation.Particle and fibre toxicology · 2013Article
- The possible roles of human Alu elements in aging.Frontiers in genetics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRetrotransposons have been extensively studied in plants and animals and have been shown to have an impact on human genome dynamics and evolution. Their ability to move within genomes gives retrotransposons to affect genome instability.
methodswe examined the polymorphic inserted AluYa5, evolutionary young Alu, in the progesterone receptor gene to determine the effects of Alu insertion on molecular environment. We used mono-allelic inserted cell lines which carry both Alu-present and Alu-absent alleles. To determine the epigenetic change and gene expression, we performed restriction enzyme digestion, Pyrosequencing, and Chromatin Immunoprecipitation.
resultsWe observed that the polymorphic insertion of evolutionally young Alu causes increasing levels of DNA methylation in the surrounding genomic area and generates inactive histone tail modifications. Consequently the Alu insertion deleteriously inactivates the neighboring gene expression.
conclusionThe mono-allelic Alu insertion cell line clearly showed that polymorphic inserted repetitive elements cause the inactivation of neighboring gene expression, bringing aberrant epigenetic changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.