ArticleBiomicrofluidics2012
Resolution limit for DNA barcodes in the Odijk regime.
Article in Biomicrofluidics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Long reads capture simultaneous enhancer-promoter methylation status for cell-type deconvolution.Bioinformatics (Oxford, England) · 2021Article
- Single-molecule optical genome mapping in nanochannels: multidisciplinarity at the nanoscale.Essays in biochemistry · 2021Article
- Extension distribution for DNA confined in a nanochannel near the Odijk regime.The Journal of chemical physics · 2019Article
- Measuring the wall depletion length of nanoconfined DNA.The Journal of chemical physics · 2018Article
- Modeling the relaxation of internal DNA segments during genome mapping in nanochannels.Biomicrofluidics · 2016Article
- Distribution of distances between DNA barcode labels in nanochannels close to the persistence length.The Journal of chemical physics · 2015Article
- Stretching of DNA confined in nanochannels with charged walls.Biomicrofluidics · 2014Article
- Interplay between chain stiffness and excluded volume of semiflexible polymers confined in nanochannels.The Journal of chemical physics · 2014Article
- Is DNA a Good Model Polymer?Macromolecules · 2013Article
- Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics.Nature nanotechnology · 2013Review
- Beyond gel electrophoresis: microfluidic separations, fluorescence burst analysis, and DNA stretching.Chemical reviews · 2013Review
- SENSING DNA WITH ALTERNATING CURRENTS USING A NANOGAP SENSOR EMBEDDED IN A NANOCHANNEL DEVICE.Nano LIFE · 2013Article
- Modeling the relaxation time of DNA confined in a nanochannel.Biomicrofluidics · 2013Article
- Entropic depletion of DNA in triangular nanochannels.Biomicrofluidics · 2013Article
- Regulation of DNA conformations and dynamics in flows with hybrid field microfluidics.Biomicrofluidics · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We develop an approximation for the probability of optically resolving two fluorescent labels on the backbone of a DNA molecule confined in a nanochannel in the Odijk regime as a function of the fluorescence wavelength, channel size, and the properties of the DNA (persistence length and effective width). The theoretical predictions agree well with equivalent data produced by Monte Carlo simulations of a touching wormlike bead model of DNA in a high ionic strength buffer. Although the theory is only strictly valid in the limit where the effective width of the nanochannel is small compared with the persistence length of the DNA, simulations indicate that the theoretical predictions are reasonably accurate for channel widths up to two-thirds of the persistence length. Our results quantify the conjecture that DNA barcoding has kilobase pair resolution-provided the nanochannel lies in the Odijk regime.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.