ArticleCurrent women's health reviews2011
Antidepressant Use During Breastfeeding.
Article in Current women's health reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Antidepressant transfer into amniotic fluid, umbilical cord blood & breast milk: A systematic review & combined analysis.Progress in neuro-psychopharmacology & biological psychiatry · 2021Pooled it
- Antidepressant treatment for postnatal depression.The Cochrane database of systematic reviews · 2021Pooled it
- Repetitive transcranial magnetic stimulation treatment for peripartum depression: systematic review & meta-analysis.BMC pregnancy and childbirth · 2021Pooled it
- Sertraline and breastfeeding: review and meta-analysis.Archives of women's mental health · 2015Pooled it
- Antidepressant treatment for postnatal depression.The Cochrane database of systematic reviews · 2014Pooled it
- Introducing the Mother Infant Lactation Questionnaire (MILQ): A Patient-reported Outcome Measure.Plastic and reconstructive surgery. Global open · 2026Article
- Managing anxiety-related disorders from pregnancy to parenthood.Archives of gynecology and obstetrics · 2026Review
- Maternal cariprazine exposure effects on lactating offspring sterol biosynthesis.Translational psychiatry · 2026Article
- Clinical practice guidelines for obsessive-compulsive disorder: 2025 update.Indian journal of psychiatry · 2026Article
- The Interplay Between Sleep Apnea and Postpartum Depression.Neurology international · 2025Review
- Assessment of Infant Exposure to Antidepressants through Breastfeeding: A Literature Review of Currently Available Approaches.Pharmaceutics · 2024Review
- Sertraline, citalopram and paroxetine in lactation: passage into breastmilk and infant exposure.Frontiers in pharmacology · 2024Article
- Psychiatric illness and pregnancy: A literature review.Heliyon · 2023Article
- Long-Term Maternal and Child Outcomes Following Postnatal SSRI Treatment.JAMA network open · 2023Article
- Postpartum Depression and Maternal Care: Exploring the Complex Effects on Mothers and Infants.Cureus · 2023Review
- A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk.British journal of clinical pharmacology · 2020Article
- Psychotropic Treatment During Pregnancy: Research Synthesis and Clinical Care Principles.Journal of women's health (2002) · 2020Review
- Severe Brief Resolved Unexplained Event in a Newborn Infant in Association with Maternal Sertralin Treatment during Pregnancy.Medicines (Basel, Switzerland) · 2018Article
- Depression During Pregnancy and Postpartum.Current psychiatry reports · 2016Review
- The effects of gestational stress and Selective Serotonin reuptake inhibitor antidepressant treatment on structural plasticity in the postpartum brain--A translational model for postpartum depression.Hormones and behavior · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe treatment of breastfeeding mothers with depression raises several dilemmas, including the possible risk of drug exposure through breast milk for the infant. This article provides background information and presents practical advice and recommendations for the clinician dealing with the treatment of depression and related disorders in the postpartum period.
methodsAn electronic search for relevant articles was performed. As the use of tricyclic antidepressants has considerably decreased during the last decade and no new information on breastfeeding has emerged for the tricyclics in this period, this review exclusively focuses on the newer, non-tricyclic compounds.
resultsMost newer antidepressants produce very low or undetectable plasma concentrations in nursing infants. The highest infant plasma levels have been reported for fluoxetine, citalopram and venlafaxine. Suspected adverse effects have been reported in a few infants, particularly for fluoxetine and citalopram.
conclusionsInfant exposure of antidepressants through breast milk is generally low to very low. We consider that when antidepressant treatment is indicated in women with postpartum depression, they should not be advised to discontinue breastfeeding. Paroxetine and sertraline are most likely suitable first-line agents. Although some concern has been expressed for fluoxetine, citalopram and venlafaxine, we nevertheless consider that if the mother has been treated with one of these drugs during pregnancy, breast-feeding could also be allowed during continued treatment with these drugs in the postpartum period. However, an individual risk-benefit assessment should always be performed.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.