Evidence map›Paper›PMID 22298988›Full record

ArticleGastroenterology & hepatology2011

Therapeutic vaccines for gastrointestinal cancers.

Osama E Rahma, Samir N Khleif

Open access · greenAbstract read
In one paragraph

Article in Gastroenterology & hepatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
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  7. Review
  8. Review
  9. Pancreatic cancer, treatment options, and GI-4000.Human vaccines & immunotherapeutics · 2015
    Review
  10. Pancreatic cancer, treatment options, and GI-4000.Human vaccines & immunotherapeutics · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Osama E Rahma
Samir N Khleif
National Institutes of Health · US

Funding

Enhancing immune response strategies:ZIABC010755 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KHLEIF, SAMIR · 2009 to 2012
$2.4M
Clinical trial development in cancer vaccinesZIABC010757 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KHLEIF, SAMIR · 2009 to 2012
$1.4M
Anti-angiogenesis targeted vaccine therapyZIABC010752 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KHLEIF, SAMIR · 2009 to 2012
$573k
6 · The paper itself

Abstract

Despite progress in the management of gastrointestinal malignancies, these diseases remain devastating maladies. Conventional treatment with chemotherapy and radiation is still only partially effective and highly toxic. In the era of increasing knowledge of the molecular biology of tumors and the interaction between the tumor and immune system, the development of targeted agents, including cancer vaccines, has emerged as a promising modality. In this paper, we discuss the principals of vaccine development, and we review most of the published trials on gastrointestinal cancer vaccines that have been conducted over the last decade. Many antigens and various treatment approaches have already been tested in colon, pancreatic, and other cancers. Some of these approaches have already shown some clinical benefit. In this paper, we discuss these different strategies and some of the future directions for targeting gastrointestinal malignancies with vaccines.

Indexed as

Cancer vaccinegastrointestinalmalignanciesreviewtrials

Identifiers

PMID22298988
PMCPMC3264936
OpenAlexW1563989261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.