Evidence map›Paper›PMID 22298924›Full record

ArticlePublic health reports (Washington, D.C. : 1974)

Atrazine exposure in public drinking water and preterm birth.

Jessica L Rinsky, Claudia Hopenhayn, Vijay Golla, Steve Browning, Heather M Bush

Abstract read
In one paragraph

Article in Public health reports (Washington, D.C. : 1974). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Atrazine and pregnancy outcomes: a systematic review of epidemiologic evidence.Birth defects research. Part B, Developmental and reproductive toxicology · 2014
    Pooled it
  5. Article
  6. Review
  7. Article
  8. Article
  9. Epidermal growth factor receptor in placental health and disease: pathways, dysfunction, and chemical disruption.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  10. Endocrine disruptors and pregnancy.Turkish journal of medical sciences · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Drinking Water Contaminant Concentrations and Birth Outcomes.Journal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management] · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. A Higher Abundance ofMicroorganisms · 2023
    Article
  20. Characterization of Arsenic and Atrazine Contaminations in Drinking Water in Iowa: A Public Health Concern.International journal of environmental research and public health · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jessica L RinskyUniversity of Kentucky, College of Public Health, Lexington, Department of Epidemiology, Lexington, KY 40504-3381, USA.
Claudia Hopenhayn
Vijay Golla
Steve Browning
Heather M Bush
University of Kentucky · USWestern Kentucky University · US

Funding

Southeast Center for Agricultural Health and Injury PreventionU50OH007547 · OH · UNIVERSITY OF KENTUCKY · PI MCKNIGHT, ROBERT H. · 2001 to 2010
$4.7M
NIOSH CDC HHS 5U50OH007547-08NIOSH CDC HHS U50 OH007547
6 · The paper itself

Abstract

objectivesApproximately 13% of all births occur prior to 37 weeks gestation in the U.S. Some established risk factors exist for preterm birth, but the etiology remains largely unknown. Recent studies have suggested an association with environmental exposures. We examined the relationship between preterm birth and exposure to a commonly used herbicide, atrazine, in drinking water.

methodsWe reviewed Kentucky birth certificate data for 2004-2006 to collect duration of pregnancy and other individual-level covariates. We assessed existing data sources for atrazine levels in public drinking water for the years 2000-2008, classifying maternal county of residence into three atrazine exposure groups. We used logistic regression to analyze the relationship between atrazine exposure and preterm birth, controlling for maternal age, race/ethnicity, education, smoking, and prenatal care.

resultsAn increase in the odds of preterm birth was found for women residing in the counties included in the highest atrazine exposure group compared with women residing in counties in the lowest exposure group, while controlling for covariates. Analyses using the three exposure assessment approaches produced odds ratios ranging from 1.20 (95% confidence interval [CI] 1.14, 1.27) to 1.26 (95% CI 1.19, 1.32), for the highest compared with the lowest exposure group.

conclusionsSuboptimal characterization of environmental exposure and variables of interest limited the analytical options of this study. Still, our findings suggest a positive association between atrazine and preterm birth, and illustrate the need for an improved assessment of environmental exposures to accurately address this important public health issue.

Indexed as

AdultAtrazineCross-Sectional StudiesDrinking WaterEducational StatusEnvironmental ExposureFemaleGestational AgeHerbicidesHumansKentuckyLogistic ModelsPregnancyPremature BirthPrenatal CareRural PopulationAtrazineDrinking WaterHerbicides

Identifiers

PMID22298924
PMCPMC3234399
OpenAlexW2169859317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.