ArticleGenetics2012
Sensory organ remodeling in Caenorhabditis elegans requires the zinc-finger protein ZTF-16.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A Glial Hub-and-Spoke Circuitry in C. elegans orchestrates bidirectional thermosensation.Nature communications · 2026Article
- Dendrite glia interactions: lessons from theFrontiers in cell and developmental biology · 2025Review
- Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024Review
- SID-4/NCK-1 is important for dsRNA import in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2022Article
- C. elegans as a model to study glial development.The FEBS journal · 2022Review
- Inferences of glia-mediated control in Caenorhabditis elegans.Journal of neuroscience research · 2021Article
- Review
- Stress-Induced Neural Plasticity Mediated by Glial GPCR REMO-1 Promotes C. elegans Adaptive Behavior.Cell reports · 2021Article
- Building stereotypic connectivity: mechanistic insights into structural plasticity from C. elegans.Current opinion in neurobiology · 2018Review
- Coordinated morphogenesis of neurons and glia.Current opinion in neurobiology · 2017Review
- Phenotypic plasticity and remodeling in the stress-induced Caenorhabditis elegans dauer.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- [The effect of glial cells in the function and development of the nervous system in Caenorhabditis elegans].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Article
- Article
- Glial development and function in the nervous system of Caenorhabditis elegans.Cold Spring Harbor perspectives in biology · 2015Review
- Primary cilia and dendritic spines: different but similar signaling compartments.Molecules and cells · 2013Review
- Cell-type-specific promoters forJournal of neurogeneticsArticle
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Authors and funding
3 authors.
Funding
Abstract
Neurons and glia display remarkable morphological plasticity, and remodeling of glia may facilitate neuronal shape changes. The molecular basis and control of glial shape changes is not well understood. In response to environmental stress, the nematode Caenorhabditis elegans enters an alternative developmental state, called dauer, in which glia and neurons of the amphid sensory organ remodel. Here, we describe a genetic screen aimed at identifying genes required for amphid glia remodeling. We previously demonstrated that remodeling requires the Otx-type transcription factor TTX-1 and its direct target, the receptor tyrosine kinase gene ver-1. We now find that the hunchback/Ikaros-like C2H2 zinc-finger factor ztf-16 is also required. We show that ztf-16 mutants exhibit pronounced remodeling defects, which are explained, at least in part, by defects in the expression of ver-1. Expression and cell-specific rescue studies suggest that ztf-16, like ttx-1, functions within glia; however, promoter deletion studies show that ztf-16 acts through a site on the ver-1 promoter that is independent of ttx-1. Our studies identify an important component of glia remodeling and suggest that transcriptional changes may underlie glial morphological plasticity in the sensory organs of C. elegans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.