ArticleGenetics2012
Understanding and predicting the fitness decline of shrunk populations: inbreeding, purging, mutation, and standard selection.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 187 citations in OpenAlex.
- Genomic erosion in the assessment of species' extinction risk and recovery potential.The Journal of heredity · 2026Article
- Genetic diversity and genomic inbreeding trends in the Japanese Thoroughbred population.Journal of equine science · 2026Article
- Massive Genetic Diversity Loss Within Asian Elephant Subspecies: New Insights for Determining Conservation Priorities.Genome biology and evolution · 2026Article
- Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Overdominance for fitness: a genomic comparison between empirical and simulated data with Drosophila melanogaster.Genetics · 2026Article
- Runs of homozygosity in Italian Holstein bulls: a permutation approach and time-based mapping of the genomic regions potentially under selection.BMC genomics · 2026Article
- A Test of the Long-Term Efficiency of Genetic Rescue With Drosophila melanogaster.Molecular ecology · 2025Article
- Outcrossing Complicates Mutation Purging by Trapping Single Nucleotide Polymorphisms in Structural Variant Mutations.bioRxiv : the preprint server for biology · 2025Article
- Inbreeding load in finite populations from dominant and overdominant mutations.Proceedings. Biological sciences · 2025Article
- Genomes of Galápagos Mockingbirds Reveal the Impact of Island Size and Past Demography on Inbreeding and Genetic Load in Contemporary Populations.Molecular ecology · 2025Article
- Whole-Genome Evaluation of Genetic Rescue: The Case of a Curiously Isolated and Endangered Butterfly.Molecular ecology · 2025Article
- Genomic and fitness consequences of a near-extinction event in the northern elephant seal.Nature ecology & evolution · 2024Article
- Too big to purge: persistence of deleterious Mutations in Island populations of the European Barn Owl (Tyto alba).Heredity · 2024Article
- Phylogeographic Analysis for Understanding Origin, Speciation, and Biogeographic Expansion of Invasive Asian Hornet,Life (Basel, Switzerland) · 2024Article
- Article
- Ballou's Ancestral Inbreeding Coefficient: Formulation and New Estimate with Higher Reliability.Animals : an open access journal from MDPI · 2024Article
- Efficient purging of deleterious mutations contributes to the survival of a rare conifer.Horticulture research · 2024Article
- Comparative genomic analyses provide new insights into evolutionary history and conservation genomics of gorillas.BMC ecology and evolution · 2024Review
- Characterizing and Eliminating the Inbreeding Load.Veterinary sciences · 2023Review
- Genetic Load and Adaptive Potential of a Recovered Avian Species that Narrowly Avoided Extinction.Molecular biology and evolution · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The joint consequences of inbreeding, natural selection, and deleterious mutation on mean fitness after population shrinkage are of great importance in evolution and can be critical to the conservation of endangered populations. I present simple analytical equations that predict these consequences, improving and extending a previous heuristic treatment. Purge is defined as the "extra" selection induced by inbreeding, due to the "extra" fitness disadvantage (2d) of homozygotes for (partially) recessive deleterious alleles. Its effect is accounted for by using, instead of the classical inbreeding coefficient f, a purged inbreeding coefficient g that is weighed by the reduction of the frequency of deleterious alleles caused by purging. When the effective size of a large population is reduced to a smaller stable value N (with Nd ≥ 1), the purged inbreeding coefficient after t generations can be predicted as g(t) ≈ [(1 - 1/2N) g(t)(-1) + 1/2N](1 - 2d f(t)(-1)), showing how purging acts upon previously accumulated inbreeding and how its efficiency increases with N. This implies an early fitness decay, followed by some recovery. During this process, the inbreeding depression rate shifts from its ancestral value (δ) to that of the mutation-selection-drift balance corresponding to N (δ*), and standard selection cancels out the inbreeding depression ascribed to δ*. Therefore, purge and inbreeding operate only upon the remaining δ - δ*. The method is applied to the conservation strategy in which family contributions to the breeding pool are equal and is extended to make use of genealogical information. All these predictions are checked using computer simulation.
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