ArticleNucleic acids research2012
Disparity in the DNA translocase domains of SWI/SNF and ISW2.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Single-molecule imaging of SWI/SNF chromatin remodelers reveals bromodomain-mediated and cancer-mutants-specific landscape of multi-modal DNA-binding dynamics.Nature communications · 2024Article
- Energy-driven genome regulation by ATP-dependent chromatin remodellers.Nature reviews. Molecular cell biology · 2024Review
- CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation.Nature communications · 2020Article
- Structure of the primed state of the ATPase domain of chromatin remodeling factor ISWI bound to the nucleosome.Nucleic acids research · 2019Article
- In silico evidence for sequence-dependent nucleosome sliding.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers.Nature communications · 2017Article
- A glimpse into chromatin remodeling.Nature structural & molecular biology · 2017Article
- Article
- Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex.Cell reports · 2017Article
- Interdomain Communication of the Chd1 Chromatin Remodeler across the DNA Gyres of the Nucleosome.Molecular cell · 2017Article
- Structure of chromatin remodeler Swi2/Snf2 in the resting state.Nature structural & molecular biology · 2016Article
- Mechanisms of ATP-Dependent Chromatin Remodeling Motors.Annual review of biophysics · 2016Review
- Article
- Article
- H2A histone-fold and DNA elements in nucleosome activate SWR1-mediated H2A.Z replacement in budding yeast.eLife · 2015Article
- Post-translational modifications of histones that influence nucleosome dynamics.Chemical reviews · 2015Review
- Regulating the chromatin landscape: structural and mechanistic perspectives.Annual review of biochemistry · 2014Review
- Remodelling without a power stroke.EMBO reports · 2013Article
- Nucleosome sliding mechanisms: new twists in a looped history.Nature structural & molecular biology · 2013Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
An ATP-dependent DNA translocase domain consisting of seven conserved motifs is a general feature of all ATP-dependent chromatin remodelers. While motifs on the ATPase domains of the yeast SWI/SNF and ISWI families of remodelers are highly conserved, the ATPase domains of these complexes appear not to be functionally interchangeable. We found one reason that may account for this is the ATPase domains interact differently with nucleosomes even though both associate with nucleosomal DNA 17-18 bp from the dyad axis. The cleft formed between the two lobes of the ISW2 ATPase domain is bound to nucleosomal DNA and Isw2 associates with the side of nucleosomal DNA away from the histone octamer. The ATPase domain of SWI/SNF binds to the same region of nucleosomal DNA, but is bound outside of the cleft region. The catalytic subunit of SWI/SNF also appears to intercalate between the DNA gyre and histone octamer. The altered interactions of SWI/SNF with DNA are specific to nucleosomes and do not occur with free DNA. These differences are likely mediated through interactions with the histone surface. The placement of SWI/SNF between the octamer and DNA could make it easier to disrupt histone-DNA interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.