Evidence map›Paper›PMID 22298022›Full record

ReviewCell and tissue research2012

Cellular and molecular basis for endometriosis-associated infertility.

Julie A W Stilley, Julie A Birt, Kathy L Sharpe-Timms

Open access · hybridAbstract readReview
In one paragraph

Review in Cell and tissue research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 142 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Therapeutic Potential of Linalool in Endometriosis: Modulation of Oxidative Stress, Inflammation, and Apoptosis in a Rat Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Review
  6. Review
  7. Review
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  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. CSF-1-induced DC-SIGNReproductive biology and endocrinology : RB&E · 2022
    Article
  17. Review
  18. Review
  19. Review
  20. The evolutionary biology of endometriosis.Evolution, medicine, and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Julie A W StilleyDivision of Reproductive and Perinatal Research, Department of Obstetrics, Gynecology and Women's Health, The University of Missouri School of Medicine, Columbia, 65212, USA.
Julie A Birt
Kathy L Sharpe-Timms
University of Missouri · USUniversity of Missouri Hospital · US

Funding

Training Program in Hypertension, Kidney Disease & Cell BiologyT32DK007690 · NIDDK · UNIVERSITY OF IOWA · PI HUANG, CHOU-LONG, RAHMOUNI, KAMAL · 1992 to 2022
$2.8M
Mechanisms of Reduced Fecundity in Endometriosis: A role for MMPs and TIMPsR01HD057445 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI TIMMS, KATHY L · 2008 to 2012
$1.6M
NICHD NIH HHS R01 HD057445NIDDK NIH HHS T32 DK007690PHS HHS 057445
6 · The paper itself

Abstract

Endometriosis is a gynecological disease characterized by the presence of endometrial glandular epithelial and stromal cells growing in the extra-uterine environment. The disease afflicts 10%-15% of menstruating women causing debilitating pain and infertility. Endometriosis appears to affect every part of a woman's reproductive system including ovarian function, oocyte quality, embryo development and implantation, uterine function and the endocrine system choreographing the reproductive process and results in infertility or spontaneous pregnancy loss. Current treatments are laden with menopausal-like side effects and many cause cessation or chemical alteration of the reproductive cycle, neither of which is conducive to achieving a pregnancy. However, despite the prevalence, physical and psychological tolls and health care costs, a cure for endometriosis has not yet been found. We hypothesize that endometriosis causes infertility via multifaceted mechanisms that are intricately interwoven thereby contributing to our lack of understanding of this disease process. Identifying and understanding the cellular and molecular mechanisms responsible for endometriosis-associated infertility might help unravel the confounding multiplicities of infertility and provide insights into novel therapeutic approaches and potentially curative treatments for endometriosis.

Indexed as

AnimalsEmbryo ImplantationEndometriosisFemaleHumansInfertility, FemaleOocytesOvaryPregnancy

Identifiers

PMID22298022
PMCPMC3429772
OpenAlexW2055578068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.