ArticleMolecular therapy : the journal of the American Society of Gene Therapy2012
Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?
Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- In vivo engineering of CAR-T cells: delivery strategies and clinical translation.Biomarker research · 2026Review
- Review
- Advances in manufacturing chimeric antigen receptor immune cell therapies.Seminars in immunopathology · 2024Review
- Long-term stability of clinical-grade lentiviral vectors for cell therapy.Molecular therapy. Methods & clinical development · 2024Article
- CAR T cells for hematological malignancies.The Journal of clinical investigation · 2024Article
- Kymriah® (tisagenlecleucel) - An overview of the clinical development journey of the first approved CAR-T therapy.Human vaccines & immunotherapeutics · 2023Article
- Delivery of gene editing therapeutics.Nanomedicine : nanotechnology, biology, and medicine · 2023Review
- Replication competent retrovirus testing (RCR) in the National Gene Vector Biorepository: No evidence of RCR in 1,595 post-treatment peripheral blood samples obtained from 60 clinical trials.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Current updates of CRISPR/Cas9-mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management.Cancer communications (London, England) · 2022Review
- Article
- Inadvertent Transfer of Murine VL30 Retrotransposons to CAR-T Cells.Advances in cell and gene therapy · 2022Article
- Cellular Proteo-Transcriptomic Changes in the Immediate Early-Phase of Lentiviral Transduction.Microorganisms · 2021Article
- Lipid- and Polymer-Based Nanoparticle Systems for the Delivery of CRISPR/Cas9.Journal of drug delivery science and technology · 2021Article
- CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?Molecular therapy : the journal of the American Society of Gene Therapy · 2020Review
- Gene editing for immune cell therapies.Nature biotechnology · 2019Review
- Screening Clinical Cell Products for Replication Competent Retrovirus: The National Gene Vector Biorepository Experience.Molecular therapy. Methods & clinical development · 2018Article
- Clinical use of lentiviral vectors.Leukemia · 2018Review
- Absence of Replication-Competent Retrovirus in Vectors, T Cell Products, and Patient Follow-Up Samples.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Seek and You Will Not Find: Ending the Hunt for Replication-Competent Retroviruses during Human Gene Therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.