ArticleArchives of pharmacal research2012
Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV).
Article in Archives of pharmacal research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Drug target of natural products and COVID-19: how far has science progressed?Annals of medicine and surgery (2012) · 2023Article
- COVID-19 signalome: Potential therapeutic interventions.Cellular signalling · 2023Review
- NASAFYTOLFrontiers in nutrition · 2023Article
- In vitro testing and computational analysis of specific phytochemicals with antiviral activities considering their possible applications against COVID-19.South African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges · 2022Article
- Pharmacological Potential of Flavonoids against Neurotropic Viruses.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp).Molecules (Basel, Switzerland) · 2021Article
- Polyphenols as promising biologically active substances for preventing SARS-CoV-2: A review with research evidence and underlying mechanisms.Food bioscience · 2021Review
- A role for quercetin in coronavirus disease 2019 (COVID-19).Phytotherapy research : PTR · 2021Review
- Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources.Frontiers in pharmacology · 2021Review
- Flavonoids: A complementary approach to conventional therapy of COVID-19?Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2021Review
- Natural Bioactive Molecules as Potential Agents Against SARS-CoV-2.Frontiers in pharmacology · 2021Review
- Flavonoids as Molecules With Anti-Frontiers in microbiology · 2021Review
- Polyphenols as alternative treatments of COVID-19.Computational and structural biotechnology journal · 2021Article
- Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury.Molecules (Basel, Switzerland) · 2020Review
- Micronutrients as immunomodulatory tools for COVID-19 management.Clinical immunology (Orlando, Fla.) · 2020Review
- Phytochemicals containing biologically active polyphenols as an effective agent against Covid-19-inducing coronavirus.Journal of functional foods · 2020Review
- Roles of flavonoids against coronavirus infection.Chemico-biological interactions · 2020Review
- Synergistic antiviral effects against SARS-CoV-2 by plant-based molecules.Plant cell reports · 2020Article
- The Inhibitory Activities and Antiviral Mechanism of Medicinal Plant Ingredient Quercetin Against Grouper Iridovirus Infection.Frontiers in microbiology · 2020Article
- Synthesis andAdvanced biomedical research · 2018Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it was of our interest to test the antiviral activity of the quercetin derivatives with an arylmethyl group attached. In this study, we prepared a series of the 7-O-arylmethylquercetin derivatives with various aromatic substituents and evaluated their antiviral activity against the SARS-associated coronavirus (SARS-CoV, SCV) as well as hepatitis C virus (HCV). Single difference in the aromatic substituent fine-tuned the biological activity of the 7-O-arylmethylquercetin derivatives to result in two different classes of derivatives selectively active against SCV and HCV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.