ArticleArchives of pharmacal research2012
Antitrypanosomal activities and cytotoxicity of some novel imido-substituted 1,4-naphthoquinone derivatives.
Article in Archives of pharmacal research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives.Bioorganic & medicinal chemistry · 2016Article
- 2-Chloro-N-(2-chloro-benzo-yl)-N-(2-ethyl-4-oxo-3,4-di-hydro-quinazolin-3-yl)benzamide.Acta crystallographica. Section E, Structure reports online · 2014Article
- N-(3-Chloro-1,4-dioxo-1,4-di-hydro-naph-thalen-2-yl)-N-propionylpropionamide.Acta crystallographica. Section E, Structure reports online · 2014Article
- Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives.Molecules (Basel, Switzerland) · 2013Article
- N-Butanoyl-N-(3-chloro-1,4-dioxonaph-thalen-2-yl)butanamide.Acta crystallographica. Section E, Structure reports online · 2013Article
- N-(1,4-Dioxo-1,4-dihydro-naphthalen-2-yl)benzamide.Acta crystallographica. Section E, Structure reports online · 2012Article
- N-Benzoyl-N-(1,4-dioxonaphthalen-2-yl)benzamide.Acta crystallographica. Section E, Structure reports online · 2012Article
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Authors and funding
10 authors.
Funding
Abstract
The antitrypanosomal activities, cytotoxicity, and selectivity indices of eleven imido-substituted 1,4-naphthoquinone derivatives and nifurtimox have been studied. Compared to nifurtimox (IC(50) = 10.67 μM), all the imido-naphthoquinone analogs (IMDNQ1-IMDNQ11) are more potent on Trypanosoma cruzi with IC50 values ranging from 0.7 μM to 6.1 μM (p < 0.05). Studies of the cytotoxic activities of these compounds on a Balb/C 3T3 mouse fibroblast cell line revealed that four of these compounds, IMDNQ1, IMDNQ2, IMDNQ3, and IMDNQ10 displayed selectivity indices of 60.25, 53.97, 31.83, and 275.3, respectively, rendering them significantly (p < 0.05) more selective in inhibiting the parasite growth than nifurtimox (selectivity index = 10.86).
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