Evidence map›Paper›PMID 22297674›Full record

Trial reportKidney international2012

Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets.

David M Spiegel, Kate Brady

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00974532 (Analysis of Calcium Balance in Chronic Kidney Disease), which is not on this map. Cited by 83 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 3 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00974532 nacompletednot on this map

Analysis of Calcium Balance in Chronic Kidney Disease

TypeinterventionalSponsorUniversity of Colorado, DenverRan2008 to 2012Enrolled16ConditionsChronic Kidney DiseaseArmsHigh calcium diet 2000 mg/day, Low calcium diet, 800 mg/day
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 3 syntheses or guidelines pooled it, 198 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Effects of sucroferric oxyhydroxide and sevelamer carbonate on chronic kidney disease-mineral bone disorder parameters in dialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019
    Trial
  6. Trial
  7. Trial
  8. Trial
  9. Effects of phosphate binders in moderate CKD.Journal of the American Society of Nephrology : JASN · 2012
    Trial
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Calcium Supplementation- Efficacy and Safety.Current osteoporosis reports · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David M SpiegelUniversity of Colorado, Denver, Colorado 80220, USA. david.spiegel@ucdenver.edu
Kate Brady
University of Colorado Denver · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
NCRR NIH HHS UL1 RR025780
6 · The paper itself

Abstract

Calcium balance in chronic kidney disease is poorly understood as calcium deficiency is a stimulus for secondary hyperparathyroidism and consequent bone loss while calcium excess promotes extraosseous calcifications. To help resolve this, we evaluated calcium balance in normal individuals and in patients with chronic kidney disease (CKD) on daily diets containing 800 and 2000 mg elemental calcium. Both normal individuals and patients with late stage 3 and stage 4 CKD were in slightly negative to neutral calcium balance on the 800-mg calcium diet. Normal individuals were in modest positive calcium balance on the 2000-mg diet, while patients with CKD on the same diet were in marked positive calcium balance at least over the 9 days of study; and significantly greater than the normal individuals. Increased calcium intake significantly decreased 1,25-dihydroxy-vitamin D and intact parathyroid hormone levels but did not alter the serum calcium concentration. Thus, our findings have important implications for both preventing calcium deficiency and loading in individuals with late stage 3 and stage 4 CKD.

Indexed as

AdultAgedBiomarkersCalciumCalcium, DietaryChronic DiseaseColoradoCreatinineCross-Over StudiesFemaleGlomerular Filtration RateHomeostasisHumansKidneyKidney DiseasesMale1,25-dihydroxyvitamin DBiomarkersCalciumCalcium, DietaryCreatinineParathyroid HormonePTH protein, humanVitamin D

Identifiers

PMID22297674
PMCPMC3352985
OpenAlexW2085013004

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.