Trial reportKidney international2012
The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers.
Trial report in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Urinary Response to Consuming Plant-Based Meat Alternatives in Persons with Normal Kidney Function: The SWAP-MEAT Pilot Trial.Clinical journal of the American Society of Nephrology : CJASN · 2024Trial
- A clinical audit of changes in urine pH during the nutritional rehabilitation of adolescent and young adult patients hospitalised with a restrictive eating disorder.Journal of eating disorders · 2026Article
- Urinary health indicators in folivorous-frugivorous primates with and without food supplementation.Primates; journal of primatology · 2025Article
- Medical treatment of uric acid kidney stones.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Article
- Proton pump inhibitors use is associated with a higher prevalence of kidney stones: NHANES 2007-2018.BMC public health · 2024Article
- Effects of two commercial diets and two supplements on urinary pH in dogs.Veterinary medicine and science · 2023Article
- [Diurnal differences in acute gout attacks: A clinical study of male gout patients].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Estimating 24-hour urinary excretion using spot urine measurements in kidney stone formers.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Circadian clocks of the kidney: function, mechanism, and regulation.Physiological reviews · 2022Review
- Evaluation of urinary acidification in children: Clinical utility.Frontiers in pediatrics · 2022Review
- Uric Acid and Urate in Urolithiasis: The Innocent Bystander, Instigator, and Perpetrator.Seminars in nephrology · 2020Review
- Urinary supersaturation on fractioned urine collections: which urine sample can explain better the variability observed on 24-h urine? A proof-of-concept study.Urolithiasis · 2020Observational
- Anthropometric variables, physical activity and dietary intakes of patients with uric acid nephrolithiasis.Urolithiasis · 2020Observational
- Circadian rhythms and the kidney.Nature reviews. Nephrology · 2018Review
- Biochemical and dietary factors of uric acid stone formation.Urolithiasis · 2018Article
- Optimization of urinary dipstick pH: Are multiple dipstick pH readings reliably comparable to commercial 24-hour urinary pH?Investigative and clinical urology · 2017Article
- Treatment of patients with uric acid stones.Urolithiasis · 2016Review
- Metabolic disorders: stones as first clinical manifestation of significant diseases.World journal of urology · 2015Article
- Role of insulin resistance in uric acid nephrolithiasis.World journal of nephrology · 2014Review
- Pathophysiological and physicochemical basis of ammonium urate stone formation in dolphins.The Journal of urology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Many biological functions follow circadian rhythms driven by internal and external cues that synchronize and coordinate organ physiology to diurnal changes in the environment and behavior. Urinary acid-base parameters follow diurnal patterns and it is thought these changes are due to periodic surges in gastric acid secretion. Abnormal urine pH is a risk factor for specific types of nephrolithiasis and uric acid stones result from excessively low urine pH. Here we placed 9 healthy volunteers and 10 uric acid stone formers on fixed metabolic diets to study the diurnal pattern of urinary acidification. All showed clear diurnal trends in urinary acidification, but none of the patterns were affected by inhibitors of the gastric proton pump. Uric acid stone formers had similar patterns of change throughout the day but their urine pH was always lower compared to healthy volunteers. Uric acid stone formers excreted more acid (normalized to acid ingestion), with the excess excreted primarily as titratable acid rather than ammonium. Urine base excretion was also lower in uric acid stone formers (normalized to base ingestion), along with lower plasma bicarbonate concentrations during part of the day. Thus, increased net acid presentation to the kidney and the preferential use of buffers, other than ammonium, result in much higher concentrations of undissociated uric acid throughout the day and consequently an increased risk of uric acid stones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.